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10.1073/pnas.1605259113

http://scihub22266oqcxt.onion/10.1073/pnas.1605259113
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C5024647!5024647!27531962
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suck abstract from ncbi


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pmid27531962      Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (35): E5117-24
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  • Curvature?undulation coupling as a basis for curvature sensing and generation in bilayer membranes #MMPMID27531962
  • Bradley RP; Radhakrishnan R
  • Proc Natl Acad Sci U S A 2016[Aug]; 113 (35): E5117-24 PMID27531962show ga
  • Most intracellular trafficking and many intercellular communications are orchestrated by curvature-driven or curvature-associated cellular processes. Hence, understanding how proteins sculpt lipid bilayers is vital to our understanding of how cell membranes modulate cell signaling pathways and consequent cell fate. In this study, we present coarse-grained molecular dynamics simulations of the epsin N-terminal homology domain interacting with a lipid bilayer and demonstrate a cooperative and fluctuation-mediated mechanism by which these proteins can generate curvature in bilayer membranes as well as sense curvature at large distances compared with their size.
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