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10.1073/pnas.1607794113 http://scihub22266oqcxt.onion/10.1073/pnas.1607794113 C5024639!5024639!27528664     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (35): 9846-51 Nephropedia Template TP {{tp|p=27528664|t=2016. Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing |pdf=|usr=}}{{27528664}} gab.com Text Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27528664 #FOAvip While we age, our body accumulates random somatic mutations. These mutations spontaneously arise from endogenous and exogenous sources, such as DNA replication errors or environmental insults like smoking or sunlight. Direct measurement of rare mutations could help us understand the role of somatic mutations in human aging, normal biology, and disease processes. Here, we develop the bottleneck sequencing system (BotSeqS) as a simple genome-wide sequencing-based method that accurately quantitates nuclear and mitochondrial mutational load in normal human tissues. We demonstrate that mutation prevalence and spectrum vary depending on age, tissue type, DNA repair capacity, and carcinogen exposure. Our results suggest a varied landscape of rare mutations within the human body that has yet to be explored. Twit Text FOAVip Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27528664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27528664 #FOAvip English Wikipedia <ref>{{Cite pmid|27528664}}</ref> Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing #MMPMID27528664 Hoang ML; Kinde I; Tomasetti C; McMahon KW; Rosenquist TA; Grollman AP; Kinzler KW; Vogelstein B; Papadopoulos N Proc Natl Acad Sci U S A 2016[Aug]; 113 (35): 9846-51 PMID27528664show ga While we age, our body accumulates random somatic mutations. These mutations spontaneously arise from endogenous and exogenous sources, such as DNA replication errors or environmental insults like smoking or sunlight. Direct measurement of rare mutations could help us understand the role of somatic mutations in human aging, normal biology, and disease processes. Here, we develop the bottleneck sequencing system (BotSeqS) as a simple genome-wide sequencing-based method that accurately quantitates nuclear and mitochondrial mutational load in normal human tissues. We demonstrate that mutation prevalence and spectrum vary depending on age, tissue type, DNA repair capacity, and carcinogen exposure. Our results suggest a varied landscape of rare mutations within the human body that has yet to be explored. äGenome-wide quantification of rare somatic mutations in normal human t(epmc).pdf DeepDyve Pubget Overpricing