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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (35): 9922-7 Nephropedia Template TP
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Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla #MMPMID27528671
Dum RP; Levinthal DJ; Strick PL
Proc Natl Acad Sci U S A 2016[Aug]; 113 (35): 9922-7 PMID27528671show ga
How does the ?mind? (brain) influence the ?body? (internal organs)? We identified key areas in the primate cerebral cortex that are linked through multisynaptic connections to the adrenal medulla. The most substantial influence originates from a broad network of motor areas that are involved in all aspects of skeletomotor control from response selection to motor preparation and movement execution. A smaller influence originates from a network in medial prefrontal cortex that is involved in the regulation of cognition and emotion. Thus, cortical areas involved in the control of movement, cognition, and affect are potential sources of central commands to influence sympathetic arousal. These results provide an anatomical basis for psychosomatic illness where mental states can alter organ function.