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The Multifaceted Role of Perivascular Macrophages in Tumors #MMPMID27411586
Lewis CE; Harney AS; Pollard JW
Cancer Cell 2016[Jul]; 30 (1): 18-25 PMID27411586show ga
Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, various steps in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to frontline therapies like irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention, and function of these cells could identify important targets for anti-cancer therapeutics.