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10.1186/s12911-016-0358-4 http://scihub22266oqcxt.onion/10.1186/s12911-016-0358-4 C5024416!5024416!27629872     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med+Inform+Decis+Mak 2016 ; 16 (ä): ä Nephropedia Template TP {{tp|p=27629872|t=2016. An information model for computable cancer phenotypes |pdf=|usr=}}{{27629872}} gab.com Text An information model for computable cancer phenotypes JO: BMC Med Inform Decis Mak http://www.kidney.de/pget.php?&tw=1&pmid=27629872 #FOAvip Background: Standards, methods, and tools supporting the integration of clinical data and genomic information are an area of significant need and rapid growth in biomedical informatics. Integration of cancer clinical data and cancer genomic information poses unique challenges, because of the high volume and complexity of clinical data, as well as the heterogeneity and instability of cancer genome data when compared with germline data. Current information models of clinical and genomic data are not sufficiently expressive to represent individual observations and to aggregate those observations into longitudinal summaries over the course of cancer care. These models are acutely needed to support the development of systems and tools for generating the so called clinical ?deep phenotype? of individual cancer patients, a process which remains almost entirely manual in cancer research and precision medicine. Methods: Reviews of existing ontologies and interviews with cancer researchers were used to inform iterative development of a cancer phenotype information model. We translated a subset of the Fast Healthcare Interoperability Resources (FHIR) models into the OWL 2 Description Logic (DL) representation, and added extensions as needed for modeling cancer phenotypes with terms derived from the NCI Thesaurus. Models were validated with domain experts and evaluated against competency questions. Results: The DeepPhe Information model represents cancer phenotype data at increasing levels of abstraction from mention level in clinical documents to summaries of key events and findings. We describe the model using breast cancer as an example, depicting methods to represent phenotypic features of cancers, tumors, treatment regimens, and specific biologic behaviors that span the entire course of a patient?s disease. Conclusions: We present a multi-scale information model for representing individual document mentions, document level classifications, episodes along a disease course, and phenotype summarization, linking individual observations to high-level summaries in support of subsequent integration and analysis. Twit Text FOAVip An information model for computable cancer phenotypes ????BMC Med Inform Decis Mak http://www.kidney.de/pget.php?&tw=1&pmid=27629872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27629872 #FOAvip English Wikipedia <ref>{{Cite pmid|27629872}}</ref> An information model for computable cancer phenotypes #MMPMID27629872 Hochheiser H; Castine M; Harris D; Savova G; Jacobson RS BMC Med Inform Decis Mak 2016[]; 16 (ä): ä PMID27629872show ga Background: Standards, methods, and tools supporting the integration of clinical data and genomic information are an area of significant need and rapid growth in biomedical informatics. Integration of cancer clinical data and cancer genomic information poses unique challenges, because of the high volume and complexity of clinical data, as well as the heterogeneity and instability of cancer genome data when compared with germline data. Current information models of clinical and genomic data are not sufficiently expressive to represent individual observations and to aggregate those observations into longitudinal summaries over the course of cancer care. These models are acutely needed to support the development of systems and tools for generating the so called clinical ?deep phenotype? of individual cancer patients, a process which remains almost entirely manual in cancer research and precision medicine. Methods: Reviews of existing ontologies and interviews with cancer researchers were used to inform iterative development of a cancer phenotype information model. We translated a subset of the Fast Healthcare Interoperability Resources (FHIR) models into the OWL 2 Description Logic (DL) representation, and added extensions as needed for modeling cancer phenotypes with terms derived from the NCI Thesaurus. Models were validated with domain experts and evaluated against competency questions. Results: The DeepPhe Information model represents cancer phenotype data at increasing levels of abstraction from mention level in clinical documents to summaries of key events and findings. We describe the model using breast cancer as an example, depicting methods to represent phenotypic features of cancers, tumors, treatment regimens, and specific biologic behaviors that span the entire course of a patient?s disease. Conclusions: We present a multi-scale information model for representing individual document mentions, document level classifications, episodes along a disease course, and phenotype summarization, linking individual observations to high-level summaries in support of subsequent integration and analysis. äAn information model for computable cancer phenotypes (epmc).pdf DeepDyve Pubget Overpricing