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10.1038/onc.2016.15 http://scihub22266oqcxt.onion/10.1038/onc.2016.15 C5024152!5024152!26876206     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2016 ; 35 (36): 4816-27 Nephropedia Template TP {{tp|p=26876206|t=2016. Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/?-catenin signaling |pdf=|usr=}}{{26876206}} gab.com Text Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/ -catenin signaling JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26876206 #FOAvip Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecological malignancies owing to poor screening methods, non-specific symptoms and limited knowledge of the cellular targets that contribute to the disease. Cyclin G2 is an unconventional cyclin that acts to oppose cell cycle progression. Dysregulation of the cyclin G2 gene (CCNG2) in a variety of human cancers has been reported; however, the role of cyclin G2 in tumorigenesis remains unclear. In this study, we investigated the function of cyclin G2 in EOC. In vitro and in vivo studies using several EOC-derived tumor cell lines revealed that cyclin G2 inhibited cell proliferation, migration, invasion and spheroid formation, as well as tumor formation and invasion. By interrogating cDNA microarray data sets, we found that CCGN2 mRNA is reduced in several large cohorts of human ovarian carcinoma when compared with normal ovarian surface epithelium or borderline tumors of the ovary. Mechanistically, cyclin G2 was found to suppress epithelial-to-mesenchymal transition (EMT), as demonstrated by the differential regulation of various EMT genes, such as Snail, Slug, vimentin and E-cadherin. Moreover, cyclin G2 potently suppressed the Wnt/?-catenin signaling pathway by downregulating key Wnt components, namely LRP6, DVL2 and ?-catenin, which could be linked to inhibition of EMT. Taken together, our novel findings demonstrate that cyclin G2 has potent tumor-suppressive effects in EOCs by inhibiting EMT through attenuating Wnt/?-catenin signaling. Twit Text FOAVip Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/ -catenin signaling ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26876206 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26876206 #FOAvip English Wikipedia <ref>{{Cite pmid|26876206}}</ref> Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/?-catenin signaling #MMPMID26876206 Bernaudo S; Salem M; Qi X; Zhou W; Zhang C; Yang W; Rosman D; Deng Z; Ye G; Yang B; Vanderhyden B; Wu Z; Peng C Oncogene 2016[Sep]; 35 (36): 4816-27 PMID26876206show ga Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecological malignancies owing to poor screening methods, non-specific symptoms and limited knowledge of the cellular targets that contribute to the disease. Cyclin G2 is an unconventional cyclin that acts to oppose cell cycle progression. Dysregulation of the cyclin G2 gene (CCNG2) in a variety of human cancers has been reported; however, the role of cyclin G2 in tumorigenesis remains unclear. In this study, we investigated the function of cyclin G2 in EOC. In vitro and in vivo studies using several EOC-derived tumor cell lines revealed that cyclin G2 inhibited cell proliferation, migration, invasion and spheroid formation, as well as tumor formation and invasion. By interrogating cDNA microarray data sets, we found that CCGN2 mRNA is reduced in several large cohorts of human ovarian carcinoma when compared with normal ovarian surface epithelium or borderline tumors of the ovary. Mechanistically, cyclin G2 was found to suppress epithelial-to-mesenchymal transition (EMT), as demonstrated by the differential regulation of various EMT genes, such as Snail, Slug, vimentin and E-cadherin. Moreover, cyclin G2 potently suppressed the Wnt/?-catenin signaling pathway by downregulating key Wnt components, namely LRP6, DVL2 and ?-catenin, which could be linked to inhibition of EMT. Taken together, our novel findings demonstrate that cyclin G2 has potent tumor-suppressive effects in EOCs by inhibiting EMT through attenuating Wnt/?-catenin signaling. äCyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting (epmc).pdf DeepDyve Pubget Overpricing