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10.1002/jcp.24850 http://scihub22266oqcxt.onion/10.1002/jcp.24850 C5024069!5024069!25336110     free     free     free       J+Cell+Physiol 2015 ; 230 (5): 1148-57 Nephropedia Template TP {{tp|p=25336110|t=2015. Chondroptosis in Alkaptonuric Cartilage |pdf=|usr=}}{{25336110}} gab.com Text Chondroptosis in Alkaptonuric Cartilage JO: J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25336110 #FOAvip Alkaptonuria (AKU) is a rare genetic disease that affects the entire joint. Current standard of treatment is palliative and little is known about AKU physiopathology. Chondroptosis, a peculiar type of cell death in cartilage, has been so far reported to occur in osteoarthritis, a rheumatic disease that shares some features with AKU. In the present work, we wanted to assess if chondroptosis might also occur in AKU. Electron microscopy was used to detect the morphological changes of chondrocytes in damaged cartilage distinguishing apoptosis from its variant termed chondroptosis. We adopted histological observation together with Scanning Electron Microscopy and Transmission Electron Microscopy to evaluate morphological cell changes in AKU chondrocytes. Lipid peroxidation in AKU cartilage was detected by fluorescence microscopy. Using the above?mentioned techniques, we performed a morphological analysis and assessed that AKU chondrocytes undergo phenotypic changes and lipid oxidation, resulting in a progressive loss of articular cartilage structure and function, showing typical features of chondroptosis. To the best of our knowledge, AKU is the second chronic pathology, following osteoarthritis, where chondroptosis has been documented. Our results indicate that Golgi complex plays an important role in the apoptotic process of AKU chondrocytes and suggest a contribution of chondroptosis in AKU pathogenesis. These findings also confirm a similarity between osteoarthritis and AKU. J. Cell. Physiol. 230: 1148?1157, 2015. © 2014 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc. Twit Text FOAVip Chondroptosis in Alkaptonuric Cartilage ????J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25336110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25336110 #FOAvip English Wikipedia <ref>{{Cite pmid|25336110}}</ref> Chondroptosis in Alkaptonuric Cartilage #MMPMID25336110 Millucci L; Giorgetti G; Viti C; Ghezzi L; Gambassi S; Braconi D; Marzocchi B; Paffetti A; Lupetti P; Bernardini G; Orlandini M; Santucci A J Cell Physiol 2015[May]; 230 (5): 1148-57 PMID25336110show ga Alkaptonuria (AKU) is a rare genetic disease that affects the entire joint. Current standard of treatment is palliative and little is known about AKU physiopathology. Chondroptosis, a peculiar type of cell death in cartilage, has been so far reported to occur in osteoarthritis, a rheumatic disease that shares some features with AKU. In the present work, we wanted to assess if chondroptosis might also occur in AKU. Electron microscopy was used to detect the morphological changes of chondrocytes in damaged cartilage distinguishing apoptosis from its variant termed chondroptosis. We adopted histological observation together with Scanning Electron Microscopy and Transmission Electron Microscopy to evaluate morphological cell changes in AKU chondrocytes. Lipid peroxidation in AKU cartilage was detected by fluorescence microscopy. Using the above?mentioned techniques, we performed a morphological analysis and assessed that AKU chondrocytes undergo phenotypic changes and lipid oxidation, resulting in a progressive loss of articular cartilage structure and function, showing typical features of chondroptosis. To the best of our knowledge, AKU is the second chronic pathology, following osteoarthritis, where chondroptosis has been documented. Our results indicate that Golgi complex plays an important role in the apoptotic process of AKU chondrocytes and suggest a contribution of chondroptosis in AKU pathogenesis. These findings also confirm a similarity between osteoarthritis and AKU. J. Cell. Physiol. 230: 1148?1157, 2015. © 2014 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc. äChondroptosis in Alkaptonuric Cartilage (epmc).pdf DeepDyve Pubget Overpricing