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10.1111/jon.12219 http://scihub22266oqcxt.onion/10.1111/jon.12219 C5023998!5023998!25704766     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroimaging 2015 ; 25 (6): 861-5 Nephropedia Template TP {{tp|p=25704766|t=2015. The Molecular Mechanisms of Neural Flow Coupling: A New Concept |pdf=|usr=}}{{25704766}} gab.com Text The Molecular Mechanisms of Neural Flow Coupling: A New Concept JO: J Neuroimaging http://www.kidney.de/pget.php?&tw=1&pmid=25704766 #FOAvip The phenomenon known as neural flow coupling (NFC) occurs at the capillary level where there are no known pressure controlling structures. Recent developments in advanced magnetic resonance imaging technologies have made possible in vivo direct investigations of water physiology that have shed new insight on the water dynamics of the cortical pericapillary space and their complex functionality in relation to NFC. Neural activities initiate a chain of events that ultimately affect NFC. First, neural activities generate extracellular acidification. Extracellular acidosis in turn produces inhibition of aquaporin?4 (AQP?4) located at the end feet of pericapillary astrocytes, the water channel which regulates water influx into the pericapillary space and, hence, interstitial flow. Reduction of pericapillary water pressure results in a negative balance between pericapillary and intraluminal capillary pressure, allowing for capillary caliber expansion. Proton permeability through the tight junctions of the blood brain barrier is significantly high owing to the Grotthuss proton ?tunneling? mechanism and, therefore, carbonic anhydrase (CA) type IV (CA?IV) anchored to the luminal surface of brain capillaries functions as scavenger of extracellular protons. CA?IV inhibition by acetazolamide or carbon dioxide results in the accumulation of extracellular protons, causing AQP?4 inhibition and a secondary increase in rCBF. Twit Text FOAVip The Molecular Mechanisms of Neural Flow Coupling: A New Concept ????J Neuroimaging http://www.kidney.de/pget.php?&tw=1&pmid=25704766 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25704766 #FOAvip English Wikipedia <ref>{{Cite pmid|25704766}}</ref> The Molecular Mechanisms of Neural Flow Coupling: A New Concept #MMPMID25704766 Nakada T J Neuroimaging 2015[Nov]; 25 (6): 861-5 PMID25704766show ga The phenomenon known as neural flow coupling (NFC) occurs at the capillary level where there are no known pressure controlling structures. Recent developments in advanced magnetic resonance imaging technologies have made possible in vivo direct investigations of water physiology that have shed new insight on the water dynamics of the cortical pericapillary space and their complex functionality in relation to NFC. Neural activities initiate a chain of events that ultimately affect NFC. First, neural activities generate extracellular acidification. Extracellular acidosis in turn produces inhibition of aquaporin?4 (AQP?4) located at the end feet of pericapillary astrocytes, the water channel which regulates water influx into the pericapillary space and, hence, interstitial flow. Reduction of pericapillary water pressure results in a negative balance between pericapillary and intraluminal capillary pressure, allowing for capillary caliber expansion. Proton permeability through the tight junctions of the blood brain barrier is significantly high owing to the Grotthuss proton ?tunneling? mechanism and, therefore, carbonic anhydrase (CA) type IV (CA?IV) anchored to the luminal surface of brain capillaries functions as scavenger of extracellular protons. CA?IV inhibition by acetazolamide or carbon dioxide results in the accumulation of extracellular protons, causing AQP?4 inhibition and a secondary increase in rCBF. äThe Molecular Mechanisms of Neural Flow Coupling: A New Concept (epmc).pdf DeepDyve Pubget Overpricing