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10.1097/MD.0000000000004803 http://scihub22266oqcxt.onion/10.1097/MD.0000000000004803 C5023915!5023915 !27603392     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27603392 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Medicine+(Baltimore) 2016 ; 95 (36 ): e4803 Nephropedia Template TP {{tp|p=27603392 |t=2016. Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning |pdf=|usr=}}{{27603392 }} gab.com Text Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27603392 #FOAvip Type 2 diabetes mellitus is associated with accelerated cognitive decline. The underlying pathophysiological mechanisms still remain to be elucidated although it is known that insulin signaling modulates neurotransmitter activity, including inhibitory ?-aminobutyric acid (GABA) and excitatory glutamate (Glu) receptors. Therefore, we examined whether levels of GABA and Glu are related to diabetes status and cognitive performance.Forty-one participants with type 2 diabetes and 39 participants without type 2 diabetes underwent detailed cognitive assessments and 3-Tesla proton MR spectroscopy. The associations of neurotransmitters with type 2 diabetes and cognitive performance were examined using multivariate regression analyses controlling for age, sex, education, BMI, and percentage gray/white matter ratio in spectroscopic voxel.Analysis revealed higher GABA+ levels in participants with type 2 diabetes, in participants with higher fasting blood glucose levels and in participants with higher HbA1c levels, and higher GABA+ levels in participants with both high HbA1c levels and less cognitive performance.To conclude, participants with type 2 diabetes have alterations in the GABAergic neurotransmitter system, which are related to lower cognitive functioning, and hint at the involvement of an underlying metabolic mechanism. Twit Text FOAVip Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27603392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27603392 #FOAvip English Wikipedia <ref>{{Cite pmid|27603392 }}</ref> Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning #MMPMID27603392 van Bussel FCG ; Backes WH ; Hofman PAM ; Puts NAJ ; Edden RAE ; van Boxtel MPJ ; Schram MT ; Stehouwer CDA ; Wildberger JE ; Jansen JFA Medicine (Baltimore) 2016[Sep]; 95 (36 ): e4803 PMID27603392 show ga Type 2 diabetes mellitus is associated with accelerated cognitive decline. The underlying pathophysiological mechanisms still remain to be elucidated although it is known that insulin signaling modulates neurotransmitter activity, including inhibitory ?-aminobutyric acid (GABA) and excitatory glutamate (Glu) receptors. Therefore, we examined whether levels of GABA and Glu are related to diabetes status and cognitive performance.Forty-one participants with type 2 diabetes and 39 participants without type 2 diabetes underwent detailed cognitive assessments and 3-Tesla proton MR spectroscopy. The associations of neurotransmitters with type 2 diabetes and cognitive performance were examined using multivariate regression analyses controlling for age, sex, education, BMI, and percentage gray/white matter ratio in spectroscopic voxel.Analysis revealed higher GABA+ levels in participants with type 2 diabetes, in participants with higher fasting blood glucose levels and in participants with higher HbA1c levels, and higher GABA+ levels in participants with both high HbA1c levels and less cognitive performance.To conclude, participants with type 2 diabetes have alterations in the GABAergic neurotransmitter system, which are related to lower cognitive functioning, and hint at the involvement of an underlying metabolic mechanism. |*Cognition [MESH] |Aged [MESH] |Blood Glucose/metabolism [MESH] |Case-Control Studies [MESH] |Cognitive Dysfunction/etiology/*metabolism [MESH] |Diabetes Mellitus, Type 2/*physiopathology/*psychology [MESH] |Female [MESH] |Glutamic Acid/metabolism [MESH] |Glycated Hemoglobin/metabolism [MESH] |Gray Matter/diagnostic imaging/metabolism [MESH] |Humans [MESH] |Magnetic Resonance Imaging [MESH] |Magnetic Resonance Spectroscopy [MESH] |Male [MESH] |Middle Aged [MESH] |Neuropsychological Tests [MESH] |White Matter/diagnostic imaging/metabolism [MESH]Increased GABA concentrations in type 2 diabetes mellitus are related (epmc).pdf DeepDyve Pubget Overpricing