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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2016 ; 95
(36
): e4414
Nephropedia Template TP
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Fecal immunochemical test for colorectal cancer from a prospective cohort with
513,283 individuals: Providing detailed number needed to scope (NNS) before
colonoscopy
#MMPMID27603337
Chen CH
; Wen CP
; Tsai MK
Medicine (Baltimore)
2016[Sep]; 95
(36
): e4414
PMID27603337
show ga
The fecal immunochemical test (FIT) is underutilized, in part, because its
benefits have not been fully understood. We assessed the relationship of FIT
values with cancer incidence and mortality, and explored how repeated
administrations of FIT could aid clinicians. A cohort with 513,283 adults in
Taiwan participated in a screening program between 1994 and the end of 2007.
Colorectal cancer was identified from National Cancer Registry and not from
colonoscopy. Positive FIT was FIT???100?ng/mL. Number needed to scope (NNS) to
identify 1 cancer by different FIT values was calculated for the study time. Only
4% of subjects had FIT???100?ng/mL but contributed 40% of cancer cases, leading
to a NNS of 25 for finding 1 in this group. However, within the same
FIT???100?ng/mL, NNS was different by age: 10 for age 60 to 69 years, 42 for age
40 to 49 years, and 156 for age 20 to 39 years. Furthermore, within the same age,
NNS was different by FIT values, for instance, 66 for FIT 100 to 199?ng/mL and 12
for FIT 600 to 799?ng/mL, a difference of 5-fold for age 50 to 59 years. The
dose-response relationship of FIT can facilitate consultation regarding the need
for colonoscopy by providing a quantitative NNS for cancer risk, an index easily
understood by patients. Our conclusion made use of (a) age-dependent and (b)
quantitative interpretation of FIT values. This single cutpoint practice
obliterates a large amount of valuable cancer risk information available to
patients.