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10.1016/j.cmet.2016.08.002 http://scihub22266oqcxt.onion/10.1016/j.cmet.2016.08.002 C5023491!5023491!27568548     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2016 ; 24 (3): 402-19 Nephropedia Template TP {{tp|p=27568548|t=2016. Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance |pdf=|usr=}}{{27568548}} gab.com Text Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27568548 #FOAvip Beige adipocytes gained much attention as an alternative cellular target in anti-obesity therapy. While recent studies have identified a number of regulatory circuits that promote beige adipocyte differentiation, the molecular basis of beige adipocyte maintenance remains unknown. Here, we demonstrate that beige adipocytes progressively lose their morphological and molecular characteristics after withdrawing external stimuli, and directly acquire white-like characteristics bypassing an intermediate precursor stage. The beige-to-white adipocyte transition is tightly coupled to a decrease in mitochondria, increase in autophagy, and activation of MiT/TFE transcription factor-mediated lysosome biogenesis. The autophagy pathway is crucial for mitochondrial clearance during the transition; inhibiting autophagy by UCP1+-adipocyte-specific deletion of Atg5 or Atg12 prevents beige adipocyte loss after withdrawing external stimuli, maintenaning high thermogenic capacity and protecting against diet-induced obesity and insulin resistance. The present study uncovers a fundamental mechanism by which autophagy-mediated mitochondrial clearance controls beige adipocyte maintenance, thereby providing new opportunities to counteract obesity. Twit Text FOAVip Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27568548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27568548 #FOAvip English Wikipedia <ref>{{Cite pmid|27568548}}</ref> Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance #MMPMID27568548 Altshuler-Keylin S; Shinoda K; Hasegawa Y; Ikeda K; Hong H; Kang Q; Yang Y; Perera RM; Debnath J; Kajimura S Cell Metab 2016[Sep]; 24 (3): 402-19 PMID27568548show ga Beige adipocytes gained much attention as an alternative cellular target in anti-obesity therapy. While recent studies have identified a number of regulatory circuits that promote beige adipocyte differentiation, the molecular basis of beige adipocyte maintenance remains unknown. Here, we demonstrate that beige adipocytes progressively lose their morphological and molecular characteristics after withdrawing external stimuli, and directly acquire white-like characteristics bypassing an intermediate precursor stage. The beige-to-white adipocyte transition is tightly coupled to a decrease in mitochondria, increase in autophagy, and activation of MiT/TFE transcription factor-mediated lysosome biogenesis. The autophagy pathway is crucial for mitochondrial clearance during the transition; inhibiting autophagy by UCP1+-adipocyte-specific deletion of Atg5 or Atg12 prevents beige adipocyte loss after withdrawing external stimuli, maintenaning high thermogenic capacity and protecting against diet-induced obesity and insulin resistance. The present study uncovers a fundamental mechanism by which autophagy-mediated mitochondrial clearance controls beige adipocyte maintenance, thereby providing new opportunities to counteract obesity. äBeige adipocyte maintenance is regulated by autophagy-induced mitochon(epmc).pdf DeepDyve Pubget Overpricing