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10.1016/j.jmb.2016.07.009

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suck abstract from ncbi


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pmid27430597
      J+Mol+Biol 2016 ; 428 (19 ): 3669-82
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  • Signal Transduction at the Single-Cell Level: Approaches to Study the Dynamic Nature of Signaling Networks #MMPMID27430597
  • Handly LN ; Yao J ; Wollman R
  • J Mol Biol 2016[Sep]; 428 (19 ): 3669-82 PMID27430597 show ga
  • Signal transduction, or how cells interpret and react to external events, is a fundamental aspect of cellular function. Traditional study of signal transduction pathways involves mapping cellular signaling pathways at the population level. However, population-averaged readouts do not adequately illuminate the complex dynamics and heterogeneous responses found at the single-cell level. Recent technological advances that observe cellular response, computationally model signaling pathways, and experimentally manipulate cells now enable studying signal transduction at the single-cell level. These studies will enable deeper insights into the dynamic nature of signaling networks.
  • |*Gene Expression Regulation [MESH]
  • |*Signal Transduction [MESH]


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