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2016 ; 105
(2
): 394-400
Nephropedia Template TP
gab.com Text
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English Wikipedia
Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an
analysis of the United States Assisted Reproductive Technology Surveillance Data,
2011-2012
#MMPMID26551441
Chang J
; Boulet SL
; Jeng G
; Flowers L
; Kissin DM
Fertil Steril
2016[Feb]; 105
(2
): 394-400
PMID26551441
show ga
OBJECTIVE: To assess the characteristics of IVF cycles for which preimplantation
genetic diagnosis (PGD) was used and to evaluate indications for PGD and
treatment outcomes associated with this procedure as compared with cycles without
PGD with the data from the U.S. National ART Surveillance System. DESIGN:
Retrospective cohort study. SETTING: None. PATIENT(S): Fresh autologous cycles
that involved transfer of at least one embryo at blastocyst when available.
INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): PGD indications and age-specific
reproductive outcomes. RESULT(S): There were a total of 97,069 non-PGD cycles and
9,833 PGD cycles: 55.6% were performed for aneuploidy screening (PGD Aneuploidy),
29.1% for other reasons (PGD Other), and 15.3% for genetic testing (PGD Genetic).
In comparison to non-PGD cycles, PGD Aneuploidy cycles showed a decreased odds of
miscarriage among women 35-37 years (adjusted odds ratio [aOR] 0.62; 95% CI,
0.45-0.87) and women >37 years (aOR 0.55; 95% CI, 0.43-0.70); and an increased
odds of clinical pregnancy (aOR 1.18; 95% CI, 1.05-1.34), live-birth delivery
(aOR 1.43; 95% CI, 1.26-1.62), and multiple-birth delivery (aOR 1.98; 95% CI,
1.52-2.57) among women >37 years. CONCLUSION(S): Aneuploidy screening was the
most common indication for PGD. Use of PGD was not observed to be associated with
an increased odds of clinical pregnancy or live birth for women <35 years. PGD
for aneuploidy was associated with a decreased odds of miscarriage for women >35
years, but an increased odds of a live-birth and a multiple live-birth delivery
among women >37 years.