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10.1016/j.fertnstert.2015.10.018

http://scihub22266oqcxt.onion/10.1016/j.fertnstert.2015.10.018
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suck abstract from ncbi


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pmid26551441
      Fertil+Steril 2016 ; 105 (2 ): 394-400
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  • Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the United States Assisted Reproductive Technology Surveillance Data, 2011-2012 #MMPMID26551441
  • Chang J ; Boulet SL ; Jeng G ; Flowers L ; Kissin DM
  • Fertil Steril 2016[Feb]; 105 (2 ): 394-400 PMID26551441 show ga
  • OBJECTIVE: To assess the characteristics of IVF cycles for which preimplantation genetic diagnosis (PGD) was used and to evaluate indications for PGD and treatment outcomes associated with this procedure as compared with cycles without PGD with the data from the U.S. National ART Surveillance System. DESIGN: Retrospective cohort study. SETTING: None. PATIENT(S): Fresh autologous cycles that involved transfer of at least one embryo at blastocyst when available. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): PGD indications and age-specific reproductive outcomes. RESULT(S): There were a total of 97,069 non-PGD cycles and 9,833 PGD cycles: 55.6% were performed for aneuploidy screening (PGD Aneuploidy), 29.1% for other reasons (PGD Other), and 15.3% for genetic testing (PGD Genetic). In comparison to non-PGD cycles, PGD Aneuploidy cycles showed a decreased odds of miscarriage among women 35-37 years (adjusted odds ratio [aOR] 0.62; 95% CI, 0.45-0.87) and women >37 years (aOR 0.55; 95% CI, 0.43-0.70); and an increased odds of clinical pregnancy (aOR 1.18; 95% CI, 1.05-1.34), live-birth delivery (aOR 1.43; 95% CI, 1.26-1.62), and multiple-birth delivery (aOR 1.98; 95% CI, 1.52-2.57) among women >37 years. CONCLUSION(S): Aneuploidy screening was the most common indication for PGD. Use of PGD was not observed to be associated with an increased odds of clinical pregnancy or live birth for women <35 years. PGD for aneuploidy was associated with a decreased odds of miscarriage for women >35 years, but an increased odds of a live-birth and a multiple live-birth delivery among women >37 years.
  • |*Chromosome Aberrations [MESH]
  • |*Fertilization in Vitro [MESH]
  • |*Genetic Testing [MESH]
  • |Abortion, Spontaneous/etiology [MESH]
  • |Adult [MESH]
  • |Age Factors [MESH]
  • |Aneuploidy [MESH]
  • |Databases, Factual [MESH]
  • |Female [MESH]
  • |Fertility [MESH]
  • |Genetic Counseling [MESH]
  • |Genetic Diseases, Inborn/*diagnosis/genetics [MESH]
  • |Humans [MESH]
  • |Infertility/diagnosis/physiopathology/*therapy [MESH]
  • |Live Birth [MESH]
  • |Logistic Models [MESH]
  • |Multivariate Analysis [MESH]
  • |Odds Ratio [MESH]
  • |Predictive Value of Tests [MESH]
  • |Pregnancy [MESH]
  • |Pregnancy Rate [MESH]
  • |Pregnancy, Multiple [MESH]
  • |Preimplantation Diagnosis/*methods [MESH]
  • |Retrospective Studies [MESH]
  • |Risk Assessment [MESH]
  • |Risk Factors [MESH]
  • |Treatment Outcome [MESH]


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