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10.1371/journal.pone.0162890 http://scihub22266oqcxt.onion/10.1371/journal.pone.0162890 C5023180!5023180!27627435     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (9): ä Nephropedia Template TP {{tp|p=27627435|t=2016. Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington?s Disease |pdf=|usr=}}{{27627435}} gab.com Text Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington s Disease JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27627435 #FOAvip Background: Huntington's disease (HD) is one of several neurodegenerative disorders that have been associated with metabolic alterations. Changes in Insulin Growth Factor 1 (IGF-1) and/or insulin input to the brain may underlie or contribute to the progress of neurodegenerative processes. Here, we investigated the association over time between changes in plasma levels of IGF-1 and insulin and the cognitive decline in HD patients. Methods: We conducted a multicentric cohort study in 156 patients with genetically documented HD aged from 22 to 80 years. Among them, 146 patients were assessed at least twice with a follow-up of 3.5 ± 1.8 years. We assessed their cognitive decline using the Unified Huntington?s Disease Rating Scale, and their IGF-1 and insulin plasmatic levels, at baseline and once a year during the follow-up. Associations were evaluated using a mixed-effect linear model. Results: In the cross-sectional analysis at baseline, higher levels of IGF-1 and insulin were associated with lower cognitive scores and thus with a higher degree of cognitive impairment. In the longitudinal analysis, the decrease of all cognitive scores, except the Stroop interference, was associated with the IGF-1 level over time but not of insulin. Conclusions: IGF-1 levels, unlike insulin, predict the decline of cognitive function in HD. Twit Text FOAVip Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington s Disease ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27627435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27627435 #FOAvip English Wikipedia <ref>{{Cite pmid|27627435}}</ref> Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington?s Disease #MMPMID27627435 Salem L; Saleh N; Désaméricq G; Youssov K; Dolbeau G; Cleret L; Bourhis ML; Azulay JP; Krystkowiak P; Verny C; Morin F; Moutereau S; Bachoud-Lévi AC; Maison P PLoS One 2016[]; 11 (9): ä PMID27627435show ga Background: Huntington's disease (HD) is one of several neurodegenerative disorders that have been associated with metabolic alterations. Changes in Insulin Growth Factor 1 (IGF-1) and/or insulin input to the brain may underlie or contribute to the progress of neurodegenerative processes. Here, we investigated the association over time between changes in plasma levels of IGF-1 and insulin and the cognitive decline in HD patients. Methods: We conducted a multicentric cohort study in 156 patients with genetically documented HD aged from 22 to 80 years. Among them, 146 patients were assessed at least twice with a follow-up of 3.5 ± 1.8 years. We assessed their cognitive decline using the Unified Huntington?s Disease Rating Scale, and their IGF-1 and insulin plasmatic levels, at baseline and once a year during the follow-up. Associations were evaluated using a mixed-effect linear model. Results: In the cross-sectional analysis at baseline, higher levels of IGF-1 and insulin were associated with lower cognitive scores and thus with a higher degree of cognitive impairment. In the longitudinal analysis, the decrease of all cognitive scores, except the Stroop interference, was associated with the IGF-1 level over time but not of insulin. Conclusions: IGF-1 levels, unlike insulin, predict the decline of cognitive function in HD. äInsulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Declin(epmc).pdf DeepDyve Pubget Overpricing