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10.1242/jcs.180885 http://scihub22266oqcxt.onion/10.1242/jcs.180885 C5023047!5023047!26869226     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2016 ; 129 (7): 1305-11 Nephropedia Template TP {{tp|p=26869226|t=2016. HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes |pdf=|usr=}}{{26869226}} gab.com Text HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26869226 #FOAvip HDAC6 is a tubulin deacetylase involved in many cellular functions related to cytoskeleton dynamics including cell migration and autophagy. In addition, HDAC6 affects antigen-dependent CD4+ T cell activation. In this study, we show that HDAC6 contributes to the cytotoxic function of CD8+ T cells. Immunization studies revealed defective cytotoxic activity in vivo in the absence of HDAC6. Adoptive transfer of wild-type or Hdac6-/- CD8+ T cells to Rag1-/- mice demonstrated specific impairment in CD8+ T cell responses against vaccinia infection. Mechanistically, HDAC6-deficient cytotoxic T lymphocytes (CTLs) showed defective in vitro cytolytic activity related to altered dynamics of lytic granules, inhibited kinesin 1 ? dynactin mediated terminal transport of lytic granules to the immune synapse and deficient exocytosis, but not to target cell recognition, T cell receptor (TCR) activation or interferon (IFN?) production. Our results establish HDAC6 as an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by CTLs. Twit Text FOAVip HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26869226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26869226 #FOAvip English Wikipedia <ref>{{Cite pmid|26869226}}</ref> HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes #MMPMID26869226 Núñez-Andrade N; Iborra S; Trullo A; Moreno-Gonzalo O; Calvo E; Catalán E; Menasche G; Sancho D; Vázquez J; Yao TP; Martín-Cófreces NB; Sánchez-Madrid F J Cell Sci 2016[Apr]; 129 (7): 1305-11 PMID26869226show ga HDAC6 is a tubulin deacetylase involved in many cellular functions related to cytoskeleton dynamics including cell migration and autophagy. In addition, HDAC6 affects antigen-dependent CD4+ T cell activation. In this study, we show that HDAC6 contributes to the cytotoxic function of CD8+ T cells. Immunization studies revealed defective cytotoxic activity in vivo in the absence of HDAC6. Adoptive transfer of wild-type or Hdac6-/- CD8+ T cells to Rag1-/- mice demonstrated specific impairment in CD8+ T cell responses against vaccinia infection. Mechanistically, HDAC6-deficient cytotoxic T lymphocytes (CTLs) showed defective in vitro cytolytic activity related to altered dynamics of lytic granules, inhibited kinesin 1 ? dynactin mediated terminal transport of lytic granules to the immune synapse and deficient exocytosis, but not to target cell recognition, T cell receptor (TCR) activation or interferon (IFN?) production. Our results establish HDAC6 as an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by CTLs. äHDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocy(epmc).pdf DeepDyve Pubget Overpricing