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10.1016/j.cels.2015.08.002 http://scihub22266oqcxt.onion/10.1016/j.cels.2015.08.002 C5023010!5023010!27135800     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Syst 2015 ; 1 (2): 141-51 Nephropedia Template TP {{tp|p=27135800|t=2015. Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells |pdf=|usr=}}{{27135800}} gab.com Text Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells JO: Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27135800 #FOAvip We combine a genome-scale RNAi screen in mouse epiblast stem cells (EpiSCs) with genetic interaction, protein localization, and ?protein-level dependency? studies?a systematic technique that uncovers post-transcriptional regulation?to delineate the network of factors that control the expression of Oct4, a key regulator of pluripotency. Our data signify that there are similarities, but also fundamental differences in Oct4 regulation in EpiSCs versus embryonic stem cells (ESCs). Through multiparametric data analyses, we predict that Tox4 is associating with the Paf1C complex, which maintains cell identity in both cell types, and validate that this protein-protein interaction exists in ESCs and EpiSCs. We also identify numerous knockdowns that increase Oct4 expression in EpiSCs, indicating that, in stark contrast to ESCs, Oct4 is under active repressive control in EpiSCs. These studies provide a framework for better understanding pluripotency and for dissecting the molecular events that govern the transition from the pre-implantation to the post-implantation state. Twit Text FOAVip Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells ????Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27135800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27135800 #FOAvip English Wikipedia <ref>{{Cite pmid|27135800}}</ref> Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells #MMPMID27135800 Ding L; Paszkowski-Rogacz M; Winzi M; Chakraborty D; Theis M; Singh S; Ciotta G; Poser I; Roguev A; Chu WK; Choudhary C; Mann M; Stewart AF; Krogan N; Buchholz F Cell Syst 2015[Aug]; 1 (2): 141-51 PMID27135800show ga We combine a genome-scale RNAi screen in mouse epiblast stem cells (EpiSCs) with genetic interaction, protein localization, and ?protein-level dependency? studies?a systematic technique that uncovers post-transcriptional regulation?to delineate the network of factors that control the expression of Oct4, a key regulator of pluripotency. Our data signify that there are similarities, but also fundamental differences in Oct4 regulation in EpiSCs versus embryonic stem cells (ESCs). Through multiparametric data analyses, we predict that Tox4 is associating with the Paf1C complex, which maintains cell identity in both cell types, and validate that this protein-protein interaction exists in ESCs and EpiSCs. We also identify numerous knockdowns that increase Oct4 expression in EpiSCs, indicating that, in stark contrast to ESCs, Oct4 is under active repressive control in EpiSCs. These studies provide a framework for better understanding pluripotency and for dissecting the molecular events that govern the transition from the pre-implantation to the post-implantation state. äSystems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulati(epmc).pdf DeepDyve Pubget Overpricing