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10.1002/ppsc.201200145 http://scihub22266oqcxt.onion/10.1002/ppsc.201200145 C5022564!5022564!27642231     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Part+Part+Syst+Charact 2013 ; 30 (4): 365-73 Nephropedia Template TP {{tp|p=27642231|t=2013. Multifunctional Polymer-Coated Carbon Nanotubes for Safe Drug Delivery |pdf=|usr=}}{{27642231}} gab.com Text Multifunctional Polymer-Coated Carbon Nanotubes for Safe Drug Delivery JO: Part Part Syst Charact http://www.kidney.de/pget.php?&tw=1&pmid=27642231 #FOAvip Though progress in the use carbon nanotubes in medicine has been most encouraging for therapeutic and diagnostic applications, any translational success must involve overcoming the toxicological and surface functionalization challenges inherent in the use of such nanotubes. Ideally, a carbon nanotube-based drug delivery system would exhibit low toxicity, sustained drug release, and persist in circulation without aggregation. We report a carbon nanotube (CNT) coated with a biocompatible block-co-polymer composed of poly(lactide)-poly(ethylene glycol) (PLA-PEG) to reduce short-term and long-term toxicity, sustain drug release of paclitaxel (PTX), and prevent aggregation. The copolymer coating on the surface of CNTs significantly reduces in vitro toxicity in human umbilical vein endothelial cells (HUVEC) and U-87 glioblastoma cells. Moreover, coating reduces in vitro inflammatory response in rat lung epithelial cells. Compared to non-coated CNTs, in vivo studies show no long-term inflammatory response with CNT coated with PLA-PEG (CLP) and the surface coating significantly decreases acute toxicity by doubling the maximum tolerated dose in mice. Using polymer coatings, we can encapsulate PTX and release over one week to increase the therapeutic efficacy compared to free drugs. In vivo biodistribution and histology studies suggests a lower degree of aggregation in tissues in that CLP accumulate more in the brain and less in the spleen than the CNT-PLA (CL) formulation. Twit Text FOAVip Multifunctional Polymer-Coated Carbon Nanotubes for Safe Drug Delivery ????Part Part Syst Charact http://www.kidney.de/pget.php?&tw=1&pmid=27642231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27642231 #FOAvip English Wikipedia <ref>{{Cite pmid|27642231}}</ref> Multifunctional Polymer-Coated Carbon Nanotubes for Safe Drug Delivery #MMPMID27642231 Moore TL; Pitzer JE; Podila R; Wang X; Lewis RL; Grimes SW; Wilson JR; Skjervold E; Brown JM; Rao A; Alexis F Part Part Syst Charact 2013[Apr]; 30 (4): 365-73 PMID27642231show ga Though progress in the use carbon nanotubes in medicine has been most encouraging for therapeutic and diagnostic applications, any translational success must involve overcoming the toxicological and surface functionalization challenges inherent in the use of such nanotubes. Ideally, a carbon nanotube-based drug delivery system would exhibit low toxicity, sustained drug release, and persist in circulation without aggregation. We report a carbon nanotube (CNT) coated with a biocompatible block-co-polymer composed of poly(lactide)-poly(ethylene glycol) (PLA-PEG) to reduce short-term and long-term toxicity, sustain drug release of paclitaxel (PTX), and prevent aggregation. The copolymer coating on the surface of CNTs significantly reduces in vitro toxicity in human umbilical vein endothelial cells (HUVEC) and U-87 glioblastoma cells. Moreover, coating reduces in vitro inflammatory response in rat lung epithelial cells. Compared to non-coated CNTs, in vivo studies show no long-term inflammatory response with CNT coated with PLA-PEG (CLP) and the surface coating significantly decreases acute toxicity by doubling the maximum tolerated dose in mice. Using polymer coatings, we can encapsulate PTX and release over one week to increase the therapeutic efficacy compared to free drugs. In vivo biodistribution and histology studies suggests a lower degree of aggregation in tissues in that CLP accumulate more in the brain and less in the spleen than the CNT-PLA (CL) formulation. äMultifunctional Polymer-Coated Carbon Nanotubes for Safe Drug Delivery(epmc).pdf DeepDyve Pubget Overpricing