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10.1038/bcj.2016.61 http://scihub22266oqcxt.onion/10.1038/bcj.2016.61 C5022178!5022178 !27518241     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27518241 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Cancer+J 2016 ; 6 (8 ): e458 Nephropedia Template TP {{tp|p=27518241 |t=2016. Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts |pdf=|usr=}}{{27518241 }} gab.com Text Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts JO: Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=27518241 #FOAvip The adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they also show the limitations of this fascinating technology: CAR T cells can lead to even life-threatening off-tumor, on-target side effects if CAR T cells crossreact with healthy tissues. Here, we describe a novel modular universal CAR platform technology termed UniCAR that reduces the risk of on-target side effects by a rapid and reversible control of CAR T-cell reactivity. The UniCAR system consists of two components: (1) a CAR for an inert manipulation of T cells and (2) specific targeting modules (TMs) for redirecting UniCAR T cells in an individualized time- and target-dependent manner. UniCAR T cells can be armed against different tumor targets simply by replacement of the respective TM for (1) targeting more than one antigen simultaneously or subsequently to enhance efficacy and (2) reducing the risk for development of antigen-loss tumor variants under treatment. Here we provide 'proof of concept' for retargeting of UniCAR T cells to CD33- and/or CD123-positive acute myeloid leukemia blasts in vitro and in vivo. Twit Text FOAVip Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts ????Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=27518241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27518241 #FOAvip English Wikipedia <ref>{{Cite pmid|27518241 }}</ref> Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts #MMPMID27518241 Cartellieri M ; Feldmann A ; Koristka S ; Arndt C ; Loff S ; Ehninger A ; von Bonin M ; Bejestani EP ; Ehninger G ; Bachmann MP Blood Cancer J 2016[Aug]; 6 (8 ): e458 PMID27518241 show ga The adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they also show the limitations of this fascinating technology: CAR T cells can lead to even life-threatening off-tumor, on-target side effects if CAR T cells crossreact with healthy tissues. Here, we describe a novel modular universal CAR platform technology termed UniCAR that reduces the risk of on-target side effects by a rapid and reversible control of CAR T-cell reactivity. The UniCAR system consists of two components: (1) a CAR for an inert manipulation of T cells and (2) specific targeting modules (TMs) for redirecting UniCAR T cells in an individualized time- and target-dependent manner. UniCAR T cells can be armed against different tumor targets simply by replacement of the respective TM for (1) targeting more than one antigen simultaneously or subsequently to enhance efficacy and (2) reducing the risk for development of antigen-loss tumor variants under treatment. Here we provide 'proof of concept' for retargeting of UniCAR T cells to CD33- and/or CD123-positive acute myeloid leukemia blasts in vitro and in vivo. |*Gene Expression Regulation [MESH] |Animals [MESH] |Antigens, Neoplasm/genetics/immunology/metabolism [MESH] |Cytokines/metabolism [MESH] |Cytotoxicity, Immunologic [MESH] |Disease Models, Animal [MESH] |Genetic Vectors/genetics [MESH] |Humans [MESH] |Immunotherapy, Adoptive/methods [MESH] |Interleukin-3 Receptor alpha Subunit/genetics/immunology/metabolism [MESH] |Lentivirus/genetics [MESH] |Leukemia, Myeloid, Acute/*genetics/*immunology/pathology/therapy [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Receptors, Antigen, T-Cell/*genetics/immunology/metabolism [MESH] |Sialic Acid Binding Ig-like Lectin 3/genetics/immunology/metabolism [MESH] |T-Lymphocytes/*immunology/*metabolism [MESH] |Transduction, Genetic [MESH]Switching CAR T cells on and off: a novel modular platform for retarge(epmc).pdf DeepDyve Pubget Overpricing