Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27624396
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2016 ; 6
(ä): 33403
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Comprehensive approach for predicting toxicological effects of ionic liquids on
several biological systems using unified descriptors
#MMPMID27624396
Cho CW
; Stolte S
; Yun YS
Sci Rep
2016[Sep]; 6
(ä): 33403
PMID27624396
show ga
The challenge and opportunity for design of environmentally-benign ionic liquids
(ILs) would start from prediction of their toxicological effects on several
endpoints solely based on the structural formulas. Especially, a comprehensive
yet simple equation able to predict several biological responses to IL toxicity
is of much advantage. Therefore, based on 50 toxicity testing systems on ILs a
comprehensively approachable prediction method was developed. For the modelling,
approximately 1600 toxicity values measured by several biological systems and an
amended linear free energy relationship (LFER) model were used. Since the
toxicological activities of an IL could be differently described according to
sensitivity of toxicity testing systems, the sensitivity of each of toxicity
testing systems was also estimated in the modelling. By statistical analysis with
the calculated descriptors, a LFER model was built. Also the sensitivity value of
each system on the basis of the comprehensively approachable model was
numerically estimated. In results, it was observed that the combination of single
model and sensitivity terms was able to predict each of 50 toxicological effects
of ILs with R(2) of 0.593~0.978, and SE of 0.098~0.699 log unit, and the total
data set with R(2) of 0.901 and SE of 0.426 log unit.