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10.1038/srep33176 http://scihub22266oqcxt.onion/10.1038/srep33176 C5021977!5021977!27624652     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27624652&cmd=llinks): Failed to open stream: HTTP request failed! 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Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy |pdf=|usr=}}{{27624652}} gab.com Text Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27624652 #FOAvip Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanced age, primary age-related tauopathy or comorbidities typical to several types of dementing diseases are usually not taken into account in preclinical studies, which predominantly use young, healthy rodents. Here we investigated for the first time the neuroprotective potential of bexarotene, an FDA-approved agent, in a co-morbidity model of stroke that combines high age and tauopathy with thromboembolic cerebral ischemia. Following thromboembolic stroke bexarotene enhanced autophagy in the ischemic brain concomitantly with a reduction in lesion volume and amelioration of behavioral deficits in aged transgenic mice expressing the human P301L-Tau mutation. In in vitro studies bexarotene increased the expression of autophagy markers and reduced autophagic flux in neuronal cells expressing P301L-Tau. Bexarotene also restored mitochondrial respiration deficits in P301L-Tau neurons. These newly described actions of bexarotene add to the growing amount of compelling data showing that bexarotene is a potent neuroprotective agent, and identify a novel autophagy-modulating effect of bexarotene. Twit Text FOAVip Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27624652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27624652 #FOAvip English Wikipedia <ref>{{Cite pmid|27624652}}</ref> Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy #MMPMID27624652 Huuskonen MT; Loppi S; Dhungana H; Keksa-Goldsteine V; Lemarchant S; Korhonen P; Wojciechowski S; Pollari E; Valonen P; Koponen J; Takashima A; Landreth G; Goldsteins G; Malm T; Koistinaho J; Kanninen KM Sci Rep 2016[]; 6 (ä): ä PMID27624652show ga Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanced age, primary age-related tauopathy or comorbidities typical to several types of dementing diseases are usually not taken into account in preclinical studies, which predominantly use young, healthy rodents. Here we investigated for the first time the neuroprotective potential of bexarotene, an FDA-approved agent, in a co-morbidity model of stroke that combines high age and tauopathy with thromboembolic cerebral ischemia. Following thromboembolic stroke bexarotene enhanced autophagy in the ischemic brain concomitantly with a reduction in lesion volume and amelioration of behavioral deficits in aged transgenic mice expressing the human P301L-Tau mutation. In in vitro studies bexarotene increased the expression of autophagy markers and reduced autophagic flux in neuronal cells expressing P301L-Tau. Bexarotene also restored mitochondrial respiration deficits in P301L-Tau neurons. These newly described actions of bexarotene add to the growing amount of compelling data showing that bexarotene is a potent neuroprotective agent, and identify a novel autophagy-modulating effect of bexarotene. äBexarotene targets autophagy and is protective against thromboembolic (epmc).pdf DeepDyve Pubget Overpricing