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10.1038/srep33054

http://scihub22266oqcxt.onion/10.1038/srep33054
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suck abstract from ncbi


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pmid27624287
      Sci+Rep 2016 ; 6 (ä): 33054
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  • Six Versus Twelve Months Clopidogrel Therapy After Drug-Eluting Stenting in Patients With Acute Coronary Syndrome: An ISAR-SAFE Study Subgroup Analysis #MMPMID27624287
  • Lohaus R ; Michel J ; Mayer K ; Lahmann AL ; Byrne RA ; Wolk A ; Ten Berg JM ; Neumann FJ ; Han Y ; Adriaenssens T ; Tölg R ; Seyfarth M ; Maeng M ; Zrenner B ; Jacobshagen C ; Wöhrle J ; Kufner S ; Morath T ; Ibrahim T ; Bernlochner I ; Fischer M ; Schunkert H ; Laugwitz KL ; Mehilli J ; Kastrati A ; Schulz-Schüpke S
  • Sci Rep 2016[Sep]; 6 (ä): 33054 PMID27624287 show ga
  • In patients presenting with acute coronary syndrome (ACS) the optimal duration of dual-antiplatelet therapy after drug-eluting stent (DES) implantation remains unclear. At 6 months after intervention, patients receiving clopidogrel were randomly assigned to either a further 6-month period of placebo or clopidogrel. The primary composite endpoint was death, myocardial infarction, stent thrombosis, stroke, or major bleeding 9 months after randomization. The ISAR-SAFE trial was terminated early due to low event rates and slow recruitment. 1601/4000 (40.0%) patients presented with ACS and were randomized to 6 (n?=?794) or 12 months (n?=?807) clopidogrel. The primary endpoint occurred in 14 patients (1.8%) receiving 6 months of clopidogrel and 17 patients (2.2%) receiving 12 months; hazard ratio (HR) 0.83, 95% confidence interval (CI) 0.41-1.68, P?=?0.60. There were 2 (0.3%) cases of stent thrombosis in each group; HR 1.00, 95% CI 0.14-7.09, P?=?>0.99. Major bleeding occurred in 3 patients (0.4%) receiving 6 months clopidogrel and 5 (0.6%) receiving 12 months; HR 0.60, 95% CI 0.15-2.49, P?=?0.49. There was no significant difference in net clinical outcomes after DES implantation in ACS patients treated with 6 versus 12 months clopidogrel. Ischaemic and bleeding events were low beyond 6-months.
  • |*Drug-Eluting Stents [MESH]
  • |Acute Coronary Syndrome/*mortality/*therapy [MESH]
  • |Aged [MESH]
  • |Clopidogrel [MESH]
  • |Follow-Up Studies [MESH]
  • |Hemorrhage/etiology/mortality/prevention & control [MESH]
  • |Humans [MESH]
  • |Middle Aged [MESH]
  • |Ticlopidine/administration & dosage/adverse effects/*analogs & derivatives [MESH]


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