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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2016 ; 6
(ä): 33054
Nephropedia Template TP
gab.com Text
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English Wikipedia
Six Versus Twelve Months Clopidogrel Therapy After Drug-Eluting Stenting in
Patients With Acute Coronary Syndrome: An ISAR-SAFE Study Subgroup Analysis
#MMPMID27624287
Lohaus R
; Michel J
; Mayer K
; Lahmann AL
; Byrne RA
; Wolk A
; Ten Berg JM
; Neumann FJ
; Han Y
; Adriaenssens T
; Tölg R
; Seyfarth M
; Maeng M
; Zrenner B
; Jacobshagen C
; Wöhrle J
; Kufner S
; Morath T
; Ibrahim T
; Bernlochner I
; Fischer M
; Schunkert H
; Laugwitz KL
; Mehilli J
; Kastrati A
; Schulz-Schüpke S
Sci Rep
2016[Sep]; 6
(ä): 33054
PMID27624287
show ga
In patients presenting with acute coronary syndrome (ACS) the optimal duration of
dual-antiplatelet therapy after drug-eluting stent (DES) implantation remains
unclear. At 6 months after intervention, patients receiving clopidogrel were
randomly assigned to either a further 6-month period of placebo or clopidogrel.
The primary composite endpoint was death, myocardial infarction, stent
thrombosis, stroke, or major bleeding 9 months after randomization. The ISAR-SAFE
trial was terminated early due to low event rates and slow recruitment. 1601/4000
(40.0%) patients presented with ACS and were randomized to 6 (n?=?794) or 12
months (n?=?807) clopidogrel. The primary endpoint occurred in 14 patients (1.8%)
receiving 6 months of clopidogrel and 17 patients (2.2%) receiving 12 months;
hazard ratio (HR) 0.83, 95% confidence interval (CI) 0.41-1.68, P?=?0.60. There
were 2 (0.3%) cases of stent thrombosis in each group; HR 1.00, 95% CI 0.14-7.09,
P?=?>0.99. Major bleeding occurred in 3 patients (0.4%) receiving 6 months
clopidogrel and 5 (0.6%) receiving 12 months; HR 0.60, 95% CI 0.15-2.49,
P?=?0.49. There was no significant difference in net clinical outcomes after DES
implantation in ACS patients treated with 6 versus 12 months clopidogrel.
Ischaemic and bleeding events were low beyond 6-months.