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10.1155/2016/6802832

http://scihub22266oqcxt.onion/10.1155/2016/6802832
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C5021882!5021882!27660761
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suck abstract from ncbi


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pmid27660761      Biomed+Res+Int 2016 ; 2016 (ä): ä
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  • ProFold: Protein Fold Classification with Additional Structural Features and a Novel Ensemble Classifier #MMPMID27660761
  • Chen D; Tian X; Zhou B; Gao J
  • Biomed Res Int 2016[]; 2016 (ä): ä PMID27660761show ga
  • Protein fold classification plays an important role in both protein functional analysis and drug design. The number of proteins in PDB is very large, but only a very small part is categorized and stored in the SCOPe database. Therefore, it is necessary to develop an efficient method for protein fold classification. In recent years, a variety of classification methods have been used in many protein fold classification studies. In this study, we propose a novel classification method called proFold. We import protein tertiary structure in the period of feature extraction and employ a novel ensemble strategy in the period of classifier training. Compared with existing similar ensemble classifiers using the same widely used dataset (DD-dataset), proFold achieves 76.2% overall accuracy. Another two commonly used datasets, EDD-dataset and TG-dataset, are also tested, of which the accuracies are 93.2% and 94.3%, higher than the existing methods. ProFold is available to the public as a web-server.
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