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2016 ; 2016
(ä): 6802832
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ProFold: Protein Fold Classification with Additional Structural Features and a
Novel Ensemble Classifier
#MMPMID27660761
Chen D
; Tian X
; Zhou B
; Gao J
Biomed Res Int
2016[]; 2016
(ä): 6802832
PMID27660761
show ga
Protein fold classification plays an important role in both protein functional
analysis and drug design. The number of proteins in PDB is very large, but only a
very small part is categorized and stored in the SCOPe database. Therefore, it is
necessary to develop an efficient method for protein fold classification. In
recent years, a variety of classification methods have been used in many protein
fold classification studies. In this study, we propose a novel classification
method called proFold. We import protein tertiary structure in the period of
feature extraction and employ a novel ensemble strategy in the period of
classifier training. Compared with existing similar ensemble classifiers using
the same widely used dataset (DD-dataset), proFold achieves 76.2% overall
accuracy. Another two commonly used datasets, EDD-dataset and TG-dataset, are
also tested, of which the accuracies are 93.2% and 94.3%, higher than the
existing methods. ProFold is available to the public as a web-server.