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10.1155/2016/9890141

http://scihub22266oqcxt.onion/10.1155/2016/9890141
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C5021499!5021499!27656050
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suck abstract from ncbi


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pmid27656050      Mediators+Inflamm 2016 ; 2016 (ä): ä
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  • Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease #MMPMID27656050
  • Bryan PF; Karla C; Edgar Alejandro MT; Sara Elva EP; Gemma F; Luz C
  • Mediators Inflamm 2016[]; 2016 (ä): ä PMID27656050show ga
  • Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important players and promising therapeutic targets to control inflammation in IBD. Interestingly, it seems that microorganisms of the normal gut microbiota and probiotics are involved in sphingolipid function. However, there is a great need to investigate the role of SLs as intermediates in the crosstalk between intestinal immunity and microorganisms. This review focuses on recent investigations that describe some mechanisms involved in the regulation of cytokine profiles by SLs. We also describe the importance of gut microbiota in providing signaling molecules that favor the communication between resident bacteria and intestinal cells. This, in turn, modulates the immune response in the bowel and likely in other peripheral organs. The potential of SLs and gut microbiota as targets or therapeutic agents for IBD is also discussed.
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