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10.1371/journal.pone.0162990

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suck abstract from ncbi


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pmid27622451
      PLoS+One 2016 ; 11 (9 ): e0162990
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  • The Effects of Pre-Existing Hyponatremia and Subsequent-Developing Acute Kidney Injury on In-Hospital Mortality: A Retrospective Cohort Study #MMPMID27622451
  • Lee SW ; Baek SH ; Ahn SY ; Na KY ; Chae DW ; Chin HJ ; Kim S
  • PLoS One 2016[]; 11 (9 ): e0162990 PMID27622451 show ga
  • BACKGROUND AND OBJECTIVES: Both hyponatremia and acute kidney injury (AKI) are common and harmful in hospitalized patients. However, their combined effects on patient mortality have been little studied. METHODS: We retrospectively enrolled 19191 adult patients who were admitted for 1 year. Pre-existing hyponatremia was defined as a serum sodium level < 135 mmol/L on the first measurement of their admission. AKI was defined as a rise in serum creatinine by ? 26.5 ?mol/L or ? 1.5 times of the baseline value of creatinine during the hospital stay. RESULTS: The prevalence of pre-existing hyponatremia was 8.2%. During a median 6.0 days of hospital stay, the incidence rates of AKI and in-hospital patient mortality were 5.1% and 0.9%, respectively. Pre-existing hyponatremia independently predicted AKI development and in-hospital mortality (adjusted hazard ratio [HR] 1.300, P = 0.004; HR 2.481, P = 0.002, respectively). Pre-existing hyponatremia and subsequent development of AKI increased in-hospital mortality by 85 times, compared to the patients with normonatremia and no AKI. In subgroup analysis, the AKI group showed higher rates of de novo hypernatremia than the non-AKI group during the admission. De novo hypernatremia, which might be associated with over-correction of hyponatremia, increased in-hospital mortality (HR 3.297, P <0.001), and patients with AKI showed significantly higher rates of de novo hypernatremia than patients without AKI (16.2% vs. 1.4%, P < 0.001, respectively). CONCLUSION: Pre-existing hyponatremia may be associated with the development of AKI in hospitalized patients, and both hyponatremia and hospital-acquired AKI could have a detrimental effect on short term patient mortality, which might be related to the inappropriate correction of hyponatremia in AKI patients.
  • |*Hospital Mortality [MESH]
  • |Acute Kidney Injury/*etiology/*mortality [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Cohort Studies [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hyponatremia/*complications/*mortality/therapy [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Republic of Korea/epidemiology [MESH]
  • |Retrospective Studies [MESH]


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