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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transplant
2016 ; 16
(4
): 1312-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Successful Transplantation of Lungs From an Uncontrolled Donor After Circulatory
Death Preserved In Situ by Alveolar Recruitment Maneuvers and Assessed by Ex Vivo
Lung Perfusion
#MMPMID26603283
Valenza F
; Citerio G
; Palleschi A
; Vargiolu A
; Fakhr BS
; Confalonieri A
; Nosotti M
; Gatti S
; Ravasi S
; Vesconi S
; Pesenti A
; Blasi F
; Santambrogio L
; Gattinoni L
Am J Transplant
2016[Apr]; 16
(4
): 1312-8
PMID26603283
show ga
We developed a protocol to procure lungs from uncontrolled donors after
circulatory determination of death (NCT02061462). Subjects with cardiovascular
collapse, treated on scene by a resuscitation team and transferred to the
emergency room, are considered potential donors once declared dead. Exclusion
criteria include unwitnessed collapse, no-flow period of >15 min and low flow
>60 min. After death, lung preservation with recruitment maneuvers, continuous
positive airway pressure, and protective mechanical ventilation is applied to the
donor. After procurement, ex vivo lung perfusion (EVLP) is performed. From
November 2014, 10 subjects were considered potential donors; one of these
underwent the full process of procurement, EVLP, and transplantation. The donor
was a 46-year-old male who died because of thoracic aortic dissection. Lungs were
procured 4 h and 48 min after death, and deemed suitable for transplantation
after EVLP. Lungs were then offered to a rapidly deteriorating recipient with
cystic fibrosis (lung allocation score [LAS] 46) who consented to the transplant
in this experimental setting. Six months after transplantation, the recipient is
in good condition (forced expiratory volume in 1 s 85%) with no signs of
rejection. This protocol allowed procurement of lungs from an uncontrolled donor
after circulatory determination of death following an extended period of warm
ischemia.