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10.1111/cas.12985 http://scihub22266oqcxt.onion/10.1111/cas.12985 C5021042!5021042!27294401     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2016 ; 107 (9): 1198-205 Nephropedia Template TP {{tp|p=27294401|t=2016. Antitumor effect of novel anti?podoplanin antibody NZ?12 against malignant pleural mesothelioma in an orthotopic xenograft model |pdf=|usr=}}{{27294401}} gab.com Text Antitumor effect of novel anti podoplanin antibody NZ 12 against malignant pleural mesothelioma in an orthotopic xenograft model JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=27294401 #FOAvip Podoplanin (aggrus) is highly expressed in several types of cancers, including malignant pleural mesothelioma (MPM). Previously, we developed a rat anti?human podoplanin mAb, NZ?1, and a rat?human chimeric anti?human podoplanin antibody, NZ?8, derived from NZ?1, which induced antibody?dependent cellular cytotoxicity (ADCC) and complement?dependent cytotoxicity against podoplanin?positive MPM cell lines. In this study, we showed the antitumor effect of NZ?1, NZ?8, and NZ?12, a novel rat?human chimeric anti?human podoplanin antibody derived from NZ?1, in an MPM orthotopic xenograft SCID mouse model. Treatment with NZ?1 and rat NK (CD161a+) cells inhibited the growth of tumors and the production of pleural effusion in NCI?H290/PDPN or NCI?H226 orthotopic xenograft mouse models. NZ?8 and human natural killer (NK) (CD56+) cells also inhibited tumor growth and pleural effusion in MPM orthotopic xenograft mice. Furthermore, NZ?12 induced potent ADCC mediated by human MNC, compared with either NZ?1 or NZ?8. Antitumor effects were observed following treatment with NZ?12 and human NK (CD56+) cells in MPM orthotopic xenograft mice. In addition, combined immunotherapy using the ADCC activity of NZ?12 mediated by human NK (CD56+) cells with pemetrexed, led to enhanced antitumor effects in MPM orthotopic xenograft mice. These results strongly suggest that combination therapy with podoplanin?targeting immunotherapy using both NZ?12 and pemetrexed might provide an efficacious therapeutic strategy for the treatment of MPM. Twit Text FOAVip Antitumor effect of novel anti podoplanin antibody NZ 12 against malignant pleural mesothelioma in an orthotopic xenograft model ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=27294401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27294401 #FOAvip English Wikipedia <ref>{{Cite pmid|27294401}}</ref> Antitumor effect of novel anti?podoplanin antibody NZ?12 against malignant pleural mesothelioma in an orthotopic xenograft model #MMPMID27294401 Abe S; Kaneko MK; Tsuchihashi Y; Izumi T; Ogasawara S; Okada N; Sato C; Tobiume M; Otsuka K; Miyamoto L; Tsuchiya K; Kawazoe K; Kato Y; Nishioka Y Cancer Sci 2016[Sep]; 107 (9): 1198-205 PMID27294401show ga Podoplanin (aggrus) is highly expressed in several types of cancers, including malignant pleural mesothelioma (MPM). Previously, we developed a rat anti?human podoplanin mAb, NZ?1, and a rat?human chimeric anti?human podoplanin antibody, NZ?8, derived from NZ?1, which induced antibody?dependent cellular cytotoxicity (ADCC) and complement?dependent cytotoxicity against podoplanin?positive MPM cell lines. In this study, we showed the antitumor effect of NZ?1, NZ?8, and NZ?12, a novel rat?human chimeric anti?human podoplanin antibody derived from NZ?1, in an MPM orthotopic xenograft SCID mouse model. Treatment with NZ?1 and rat NK (CD161a+) cells inhibited the growth of tumors and the production of pleural effusion in NCI?H290/PDPN or NCI?H226 orthotopic xenograft mouse models. NZ?8 and human natural killer (NK) (CD56+) cells also inhibited tumor growth and pleural effusion in MPM orthotopic xenograft mice. Furthermore, NZ?12 induced potent ADCC mediated by human MNC, compared with either NZ?1 or NZ?8. Antitumor effects were observed following treatment with NZ?12 and human NK (CD56+) cells in MPM orthotopic xenograft mice. In addition, combined immunotherapy using the ADCC activity of NZ?12 mediated by human NK (CD56+) cells with pemetrexed, led to enhanced antitumor effects in MPM orthotopic xenograft mice. These results strongly suggest that combination therapy with podoplanin?targeting immunotherapy using both NZ?12 and pemetrexed might provide an efficacious therapeutic strategy for the treatment of MPM. äAntitumor effect of novel anti?podoplanin antibody NZ?12 against malig(epmc).pdf DeepDyve Pubget Overpricing