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10.3233/PGE-14081 http://scihub22266oqcxt.onion/10.3233/PGE-14081 C5020984!5020984!27625862     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pediatr+Genet 2014 ; 3 (1): 9-16 Nephropedia Template TP {{tp|p=27625862|t=2014. Retrotransposons and pediatric genetic disorders: Importance and implications |pdf=|usr=}}{{27625862}} gab.com Text Retrotransposons and pediatric genetic disorders: Importance and implications JO: J Pediatr Genet http://www.kidney.de/pget.php?&tw=1&pmid=27625862 #FOAvip Pediatric disorders are generally observed to have a greater genetic load than diseases occurring during adulthood. Clinical manifestations of many genetic defects including chromosomal abnormalities and mutations in specific genes appear during childhood. One of the notable mutagens in human cells is mobile DNA element. They possess the ability to move and insert themselves in new genomic locations including critical disease-causing genes. Although our cells inhibit their transport by different mechanisms, factors such as aging and environmental heavy metals have effect on increasing their activities. In this article, we try to go over the features of active human retroelements and highlight their role in the pathology of pediatric genetic disorders. We also propose two mechanisms in which aged parental gametes and embryonic exposure to environmental stresses followed by mobile elements insertion may result in de novo pediatric diseases. Twit Text FOAVip Retrotransposons and pediatric genetic disorders: Importance and implications ????J Pediatr Genet http://www.kidney.de/pget.php?&tw=1&pmid=27625862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27625862 #FOAvip English Wikipedia <ref>{{Cite pmid|27625862}}</ref> Retrotransposons and pediatric genetic disorders: Importance and implications #MMPMID27625862 Akrami SM; Habibi L J Pediatr Genet 2014[Mar]; 3 (1): 9-16 PMID27625862show ga Pediatric disorders are generally observed to have a greater genetic load than diseases occurring during adulthood. Clinical manifestations of many genetic defects including chromosomal abnormalities and mutations in specific genes appear during childhood. One of the notable mutagens in human cells is mobile DNA element. They possess the ability to move and insert themselves in new genomic locations including critical disease-causing genes. Although our cells inhibit their transport by different mechanisms, factors such as aging and environmental heavy metals have effect on increasing their activities. In this article, we try to go over the features of active human retroelements and highlight their role in the pathology of pediatric genetic disorders. We also propose two mechanisms in which aged parental gametes and embryonic exposure to environmental stresses followed by mobile elements insertion may result in de novo pediatric diseases. äRetrotransposons and pediatric genetic disorders: Importance and impli(epmc).pdf DeepDyve Pubget Overpricing