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10.4155/fmc-2016-0071 http://scihub22266oqcxt.onion/10.4155/fmc-2016-0071 C5020427!5020427 !27548565     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27548565 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Future+Med+Chem 2016 ; 8 (13 ): 1589-607 Nephropedia Template TP {{tp|p=27548565 |t=2016. H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development |pdf=|usr=}}{{27548565 }} gab.com Text H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=27548565 #FOAvip Methylation at histone 3, lysine 36 (H3K36) is a conserved epigenetic mark regulating gene transcription, alternative splicing and DNA repair. Genes encoding H3K36 methyltransferases (KMTases) are commonly overexpressed, mutated or involved in chromosomal translocations in cancer. Molecular biology studies have demonstrated that H3K36 KMTases regulate oncogenic transcriptional programs. Structural studies of the catalytic SET domain of H3K36 KMTases have revealed intriguing opportunities for design of small molecule inhibitors. Nevertheless, potent inhibitors for most H3K36 KMTases have not yet been developed, underlining the challenges associated with this target class. As we now have strong evidence linking H3K36 KMTases to cancer, drug development efforts are predicted to yield novel compounds in the near future. Twit Text FOAVip H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=27548565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27548565 #FOAvip English Wikipedia <ref>{{Cite pmid|27548565 }}</ref> H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development #MMPMID27548565 Rogawski DS ; Grembecka J ; Cierpicki T Future Med Chem 2016[Sep]; 8 (13 ): 1589-607 PMID27548565 show ga Methylation at histone 3, lysine 36 (H3K36) is a conserved epigenetic mark regulating gene transcription, alternative splicing and DNA repair. Genes encoding H3K36 methyltransferases (KMTases) are commonly overexpressed, mutated or involved in chromosomal translocations in cancer. Molecular biology studies have demonstrated that H3K36 KMTases regulate oncogenic transcriptional programs. Structural studies of the catalytic SET domain of H3K36 KMTases have revealed intriguing opportunities for design of small molecule inhibitors. Nevertheless, potent inhibitors for most H3K36 KMTases have not yet been developed, underlining the challenges associated with this target class. As we now have strong evidence linking H3K36 KMTases to cancer, drug development efforts are predicted to yield novel compounds in the near future. |Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology [MESH] |Enzyme Inhibitors/chemical synthesis/chemistry/*pharmacology [MESH] |Humans [MESH] |Methyltransferases/*antagonists & inhibitors/genetics/metabolism [MESH] |Neoplasms/*drug therapy/metabolism [MESH]H3K36 methyltransferases as cancer drug targets: rationale and perspec(epmc).pdf DeepDyve Pubget Overpricing