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10.2147/PPA.S86379

http://scihub22266oqcxt.onion/10.2147/PPA.S86379
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C5019432!5019432 !27660422
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suck abstract from ncbi


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pmid27660422
      Patient+Prefer+Adherence 2016 ; 10 (ä): 1727-37
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  • Self-administered C1 esterase inhibitor concentrates for the management of hereditary angioedema: usability and patient acceptance #MMPMID27660422
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  • Patient Prefer Adherence 2016[]; 10 (ä): 1727-37 PMID27660422 show ga
  • Hereditary angioedema (HAE) is a rare genetic disease characterized by episodic subcutaneous or submucosal swelling. The primary cause for the most common form of HAE is a deficiency in functional C1 esterase inhibitor (C1-INH). The swelling caused by HAE can be painful, disfiguring, and life-threatening. It reduces daily function and compromises the quality of life of affected individuals and their caregivers. Among different treatment strategies, replacement with C1-INH concentrates is employed for on-demand treatment of acute attacks and long-term prophylaxis. Three human plasma-derived C1-INH preparations are approved for HAE treatment in the US, the European Union, or both regions: Cinryze(®), Berinert(®), and Cetor(®); however, only Cinryze is approved for long-term prophylaxis. Postmarketing studies have shown that home therapy (self-administered or administered by a caregiver) is a convenient and safe option preferred by many HAE patients. In this review, we summarize the role of self-administered plasma-derived C1-INH concentrate therapy with Cinryze at home in the prophylaxis of HAE.
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