Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of
Multiple Sclerosis and Alzheimer s Disease?
#MMPMID27608759
Louveau A
; Da Mesquita S
; Kipnis J
Neuron
2016[Sep]; 91
(5
): 957-973
PMID27608759
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Lymphatic vasculature drains interstitial fluids, which contain the tissue's
waste products, and ensures immune surveillance of the tissues, allowing immune
cell recirculation. Until recently, the CNS was considered to be devoid of a
conventional lymphatic vasculature. The recent discovery in the meninges of a
lymphatic network that drains the CNS calls into question classic models for the
drainage of macromolecules and immune cells from the CNS. In the context of
neurological disorders, the presence of a lymphatic system draining the CNS
potentially offers a new player and a new avenue for therapy. In this review, we
will attempt to integrate the known primary functions of the tissue lymphatic
vasculature that exists in peripheral organs with the proposed function of
meningeal lymphatic vessels in neurological disorders, specifically multiple
sclerosis and Alzheimer's disease. We propose that these (and potentially other)
neurological afflictions can be viewed as diseases with a neuro-lympho-vascular
component and should be therapeutically targeted as such.
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