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10.3389/fmolb.2016.00053 http://scihub22266oqcxt.onion/10.3389/fmolb.2016.00053 C5018970!5018970!27672636     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Biosci 2016 ; 3 (ä): ä Nephropedia Template TP {{tp|p=27672636|t=2016. Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts |pdf=|usr=}}{{27672636}} gab.com Text Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts JO: Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=27672636 #FOAvip Melusin is a chaperone protein selectively expressed in heart and skeletal muscles. Melusin expression levels correlate with cardiac function in pre-clinical models and in human patients with aortic stenosis. Indeed, previous studies in several animal models indicated that Melusin plays a broad cardioprotective role in different pathological conditions. Chaperone proteins, besides playing a role in protein folding, are also able to facilitate supramolecular complex formation and conformational changes due to activation/deactivation of signaling molecules. This role sets chaperone proteins as crucial regulators of intracellular signal transduction pathways. In particular Melusin activates AKT and ERK1/2 signaling, protects cardiomyocytes from apoptosis and induces a compensatory hypertrophic response in several pathological conditions. Therefore, selective delivery of the Melusin gene in heart via cardiotropic adenoviral associated virus serotype 9 (AAV9), may represent a new promising gene-therapy approach for different cardiac pathologies. Twit Text FOAVip Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts ????Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=27672636 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27672636 #FOAvip English Wikipedia <ref>{{Cite pmid|27672636}}</ref> Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts #MMPMID27672636 Sorge M; Brancaccio M Front Mol Biosci 2016[]; 3 (ä): ä PMID27672636show ga Melusin is a chaperone protein selectively expressed in heart and skeletal muscles. Melusin expression levels correlate with cardiac function in pre-clinical models and in human patients with aortic stenosis. Indeed, previous studies in several animal models indicated that Melusin plays a broad cardioprotective role in different pathological conditions. Chaperone proteins, besides playing a role in protein folding, are also able to facilitate supramolecular complex formation and conformational changes due to activation/deactivation of signaling molecules. This role sets chaperone proteins as crucial regulators of intracellular signal transduction pathways. In particular Melusin activates AKT and ERK1/2 signaling, protects cardiomyocytes from apoptosis and induces a compensatory hypertrophic response in several pathological conditions. Therefore, selective delivery of the Melusin gene in heart via cardiotropic adenoviral associated virus serotype 9 (AAV9), may represent a new promising gene-therapy approach for different cardiac pathologies. äMelusin Promotes a Protective Signal Transduction Cascade in Stressed (epmc).pdf DeepDyve Pubget Overpricing