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2016 ; 6
(ä): 33093
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Factors associated with significant liver necroinflammation in chronic hepatitis
B patients with cirrhosis
#MMPMID27615602
Chen SS
; Yu KK
; Ling QX
; Huang C
; Li N
; Zheng JM
; Bao SX
; Cheng Q
; Zhu MQ
; Chen MQ
Sci Rep
2016[Sep]; 6
(ä): 33093
PMID27615602
show ga
We determined the association between various clinical parameters and significant
liver necroinflammation in patients with chronic hepatitis B (CHB) related
cirrhosis. Two hundred patients with CHB related cirrhosis were recruited in the
final analysis. Clinical laboratory values and characteristics were obtained from
the medical record. We performed analyses of the relationships between
independent variables and significant liver necroinflammation by using binary
logistic regression analysis and discriminant analysis. Significant liver
necroinflammation (grade?2) was found in 58.0% (80/138) of antiviral therapy
patients and 48.4% (30/62) of non antiviral therapy patients respectively. Also,
there were some significant differences in serum hepatitis B surface antigen
(HBsAg), serum hepatitis B e antigen (HBeAg) and serum hepatitis B virus (HBV)
DNA between antiviral therapy and non antiviral therapy patients. After that,
aspartate aminotransferase (AST), total bilirubin (TBIL), total bile acid (TBA),
prothrombin time (PT), aspartate aminotransferase to platelet ratio index (APRI)
and serum HBV DNA were confirmed as independent predictors of significant liver
necroinflammation in CHB patients with cirrhosis by univariate analysis and
multivariate analysis (p?=?0.002, 0.044, 0.001, 0.014, 0.01 and 0.02
respectively). Finally, receiver operating characteristic (ROC) curve analysis
and discriminant analysis validated that these six variables together have strong
predictive power to evaluate significant liver necroinflammation.
|Adult
[MESH]
|Female
[MESH]
|Hepatitis B Antigens/blood
[MESH]
|Hepatitis B virus/genetics/isolation & purification
[MESH]