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10.1021/acsmedchemlett.6b00215 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.6b00215 C5018872!5018872!27660689     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2016 ; 7 (9): 847-51 Nephropedia Template TP {{tp|p=27660689|t=2016. Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors |pdf=|usr=}}{{27660689}} gab.com Text Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=27660689 #FOAvip The protein arginine deiminases (PADs) catalyze the post-translational deimination of arginine side chains. Multiple PAD isozymes have been characterized, and abnormal PAD activity has been associated with several human disease states. PAD3 has been characterized as a modulator of cell growth via apoptosis inducing factor and has been implicated in the neurodegenerative response to spinal cord injury. Here, we describe the design, synthesis, and evaluation of conformationally constrained versions of the potent and selective PAD3 inhibitor 2. The cell activity of representative inhibitors in this series was also demonstrated for the first time by rescue of thapsigargin-induced cell death in PAD3-expressing HEK293T cells. Twit Text FOAVip Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=27660689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27660689 #FOAvip English Wikipedia <ref>{{Cite pmid|27660689}}</ref> Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors #MMPMID27660689 Jamali H; Khan HA; Tjin C; Ellman JA ACS Med Chem Lett 2016[Sep]; 7 (9): 847-51 PMID27660689show ga The protein arginine deiminases (PADs) catalyze the post-translational deimination of arginine side chains. Multiple PAD isozymes have been characterized, and abnormal PAD activity has been associated with several human disease states. PAD3 has been characterized as a modulator of cell growth via apoptosis inducing factor and has been implicated in the neurodegenerative response to spinal cord injury. Here, we describe the design, synthesis, and evaluation of conformationally constrained versions of the potent and selective PAD3 inhibitor 2. The cell activity of representative inhibitors in this series was also demonstrated for the first time by rescue of thapsigargin-induced cell death in PAD3-expressing HEK293T cells. äCellular Activity of New Small Molecule Protein Arginine Deiminase 3 ((epmc).pdf DeepDyve Pubget Overpricing