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10.1021/acsmedchemlett.6b00273

http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.6b00273
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C5018870!5018870!27660682
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suck abstract from ncbi


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pmid27660682      ACS+Med+Chem+Lett 2016 ; 7 (9): 819-21
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  • The Added Value of Assessing Ligand?Receptor Binding Kinetics in Drug Discovery #MMPMID27660682
  • Guo D; Heitman L; IJzerman AP
  • ACS Med Chem Lett 2016[Sep]; 7 (9): 819-21 PMID27660682show ga
  • In the past decade drug research community has started to appreciate the indispensable role of ligand?receptor binding kinetics (BK) in drug discovery. Next to the classical equilibrium-based drug evaluation process with affinity and potency values as outcomes, kinetic investigation of the ligand?receptor interaction can aid compound triage in the hit-to-lead campaign and provide additional information to understand the molecular mechanism of drug action. Translational models incorporating BK are emerging as well, which represent powerful tools for the prediction of in vivo effects. In this viewpoint we will summarize some recent findings and discuss and emphasize the added value of ligand?receptor binding kinetics in drug research.
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