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2016 ; 16
(7
): e38346
Nephropedia Template TP
gab.com Text
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English Wikipedia
Fibroscan Compared to FIB-4, APRI, and AST/ALT Ratio for Assessment of Liver
Fibrosis in Saudi Patients With Nonalcoholic Fatty Liver Disease
#MMPMID27642348
Fallatah HI
; Akbar HO
; Fallatah AM
Hepat Mon
2016[Jul]; 16
(7
): e38346
PMID27642348
show ga
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is being increasingly
recognized as a cause of chronic liver disease. It has also been associated with
devastating outcomes such as decompensated liver cirrhosis and hepatocellular
carcinoma, as well as diabetes and metabolic syndrome. OBJECTIVES: This study was
conducted in order to assess liver fibrosis using Fibroscan, and to compare these
results to the use of Fibrosis-4 (FIB-4) scores, AST platelet ratio index (APRI
scores), and the AST/ALT ratios on NAFLD patients. PATIENTS AND METHODS: A cross
sectional study was conducted on NAFLD patients who underwent Fibroscan
examinations between September 1, 2011 and June 30, 2014. Demographic data was
collected, including sex, age, and nationality; serum alanine aminotransferase
levels (ALT, 30 - 65 U/L), serum aspartate aminotransferase levels (AST, 15 - 37
U/L), and platelet counts (150 - 400 k/?L) were also determined. The stages of
fibrosis (F0 1 - 6, F1 6.1 - 7, F2 7 - 9, F3 9.1 - 10.3, and F4 ? 10.4) were
defined in kPa. For each patient, the AST/ALT ratio was also measured. The
results of APRI and FIB-4 were compared with the Fibroscan fibrosis scores.
RESULTS: The results of 122 patients were analyzed, including 65 (53.3%) males
with a mean age of 50.2 years (SD: 13.7; range: 18 - 86). The males were
significantly younger than the females (48.7 years (SD: 16.03) versus 51.8 years
(SD: 10.3 P = 0.05), respectively). The mean stiffness score was 12.02 (SD: 12.7)
kPa. Forty-four patients (36%) had advanced fibrosis. The mean platelet and serum
ALT levels were normal. There was a significant positive correlation between the
Fibroscan results and the AST/ALT ratios, the APRI scores, and the FIB-4 results.
Similarly, there was a significant positive correlation between age and fibrosis
score, and a significant negative correlation between platelet count and
stiffness score. CONCLUSIONS: The data showed that more than one-third of the
cohort exhibited advanced fibrosis, demonstrating the need for the early
diagnosis and treatment of NAFLD. The use of Fibroscan with other serum markers
has been shown to be helpful for the diagnosis of severe fibrosis.