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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Genet+Med
2016 ; 18
(11
): 1069-1074
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Towards a more representative morphology: clinical and ethical considerations for
including diverse populations in diagnostic genetic atlases
#MMPMID26963283
Koretzky M
; Bonham VL
; Berkman BE
; Kruszka P
; Adeyemo A
; Muenke M
; Hull SC
Genet Med
2016[Nov]; 18
(11
): 1069-1074
PMID26963283
show ga
An important gap exists in textbooks (or atlases) of dysmorphology used by
health-care professionals to help diagnose genetic syndromes. The lack of varied
phenotypic images in available atlases limits the utility of these atlases as
diagnostic tools in globally diverse populations, causing geneticists difficulty
in diagnosing conditions in individuals of different ancestral backgrounds who
may present with variable morphological features. Proposals to address the
underinclusion of images from diverse populations in existing atlases can take
advantage of the Internet and digital photography to create new resources that
take into account the broad global diversity of populations affected by genetic
disease. Creating atlases that are more representative of the global population
will expand resources available to care for diverse patients with these
conditions, many of whom have been historically underserved by the medical
system. However, such projects also raise ethical questions that are grounded in
the complex intersection of imagery, medicine, history, and race and ethnicity.
We consider here the benefits of producing such a resource while also considering
ethical and practical concerns, and we offer recommendations for the ethical
creation, structure, equitable use, and maintenance of a diverse morphological
atlas for clinical diagnosis.Genet Med 18 11, 1069-1074.