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10.1186/s12917-016-0793-6

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suck abstract from ncbi


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pmid27614611      BMC+Vet+Res 2016 ; 12 (1): ä
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  • Genital tract lesions in sexually mature Göttingen minipigs during the initial stages of experimental vaginal infection with Chlamydia trachomatis serovar D #MMPMID27614611
  • Erneholm K; Lorenzen E; Břje S; Olsen AW; Andersen P; Cassidy JP; Follmann F; Jensen HE; Agerholm JS
  • BMC Vet Res 2016[]; 12 (1): ä PMID27614611show ga
  • Background: Chlamydia is one of the most common sexually transmitted diseases in humans worldwide, causing chronic lesions in the reproductive tract. Due to its often asymptomatic course, there is limited knowledge about the initial changes in the genital tract following infection. This study employs a novel sexually mature minipig model to investigate the initial histopathological changes following vaginal infection with Chlamydia trachomatis serovar D. Results: A vaginal inoculation resulted in an infection primarily affecting the lower genital tract. The histopathological changes were characterized by a subepithelial inflammation consisting of neutrophils and mononuclear cells, followed by an increase in the number of plasma cells within the sub-epithelial stroma of the vagina. Detection of Chlamydia was associated with expression of cyclooxygenase-2 and interleukin-8 by superficial epithelial cells. The infection was self-limiting, with a duration of 7 days. Conclusion: Neutrophils, plasma cells and IL-8 have been linked with Chlamydia genital infection of unknown duration in human patients. In this study, we observe a similar pattern of local immune response/inflammation following experimental inoculation suggesting this porcine model shows promise as a model for translational chlamydia research. Electronic supplementary material: The online version of this article (doi:10.1186/s12917-016-0793-6) contains supplementary material, which is available to authorized users.
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