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10.1016/j.bpj.2016.07.028 http://scihub22266oqcxt.onion/10.1016/j.bpj.2016.07.028 C5018130!5018130!27602736     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2016 ; 111 (5): 1088-100 Nephropedia Template TP {{tp|p=27602736|t=2016. A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect |pdf=|usr=}}{{27602736}} gab.com Text A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27602736 #FOAvip The Warburg effect, or aerobic glycolysis, is marked by the increased metabolism of glucose to lactate in the presence of oxygen. Despite its widespread prevalence in physiology and cancer biology, the causes and consequences remain incompletely understood. Here, we show that a simple balance of interacting fluxes in glycolysis creates constraints that impose the necessary conditions for glycolytic flux to generate lactate as opposed to entering into the mitochondria. These conditions are determined by cellular redox and energy demands. By analyzing the constraints and sampling the feasible region of the model, we further study how cell proliferation rate and mitochondria-associated NADH oxidizing and ATP producing fluxes are interlinked. Together this analysis illustrates the simplicity of the origins of the Warburg effect by identifying the flux distributions that are necessary for its instantiation. Twit Text FOAVip A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27602736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602736 #FOAvip English Wikipedia <ref>{{Cite pmid|27602736}}</ref> A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect #MMPMID27602736 Dai Z; Shestov A; Lai L; Locasale J Biophys J 2016[Sep]; 111 (5): 1088-100 PMID27602736show ga The Warburg effect, or aerobic glycolysis, is marked by the increased metabolism of glucose to lactate in the presence of oxygen. Despite its widespread prevalence in physiology and cancer biology, the causes and consequences remain incompletely understood. Here, we show that a simple balance of interacting fluxes in glycolysis creates constraints that impose the necessary conditions for glycolytic flux to generate lactate as opposed to entering into the mitochondria. These conditions are determined by cellular redox and energy demands. By analyzing the constraints and sampling the feasible region of the model, we further study how cell proliferation rate and mitochondria-associated NADH oxidizing and ATP producing fluxes are interlinked. Together this analysis illustrates the simplicity of the origins of the Warburg effect by identifying the flux distributions that are necessary for its instantiation. äA Flux Balance of Glucose Metabolism Clarifies the Requirements of the(epmc).pdf DeepDyve Pubget Overpricing