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10.1016/j.cell.2016.07.046 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.07.046 C5017923!5017923!27569912     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27569912&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 166 (6): 1485-1499.e15 Nephropedia Template TP {{tp|p=27569912|t=2016. ?? T Cells Support Pancreatic Oncogenesis by Restraining ?? T Cell Activation |pdf=|usr=}}{{27569912}} gab.com Text T Cells Support Pancreatic Oncogenesis by Restraining T Cell Activation JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27569912 #FOAvip Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely-activated ??T cell population which constituted ?40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of ??T cells was contingent on diverse chemokine signals. Deletion, depletion, or blockade of ??T cell recruitment was protective against PDA and resulted in increased infiltration, activation, and Th1-polarization of ??T cells. Whereas ??T cells were dispensable to outcome in PDA, they became indispensable mediators of tumor-protection upon ??T cell ablation. PDA-infiltrating ??T cells expressed high levels of exhaustion ligands and thereby negated adaptive anti-tumor immunity. Blockade of PD-L1 in ??T cells enhanced CD4+ and CD8+ T cell infiltration and immunogenicity and induced tumor-protection suggesting that ??T cells are critical sources of immune-suppressive checkpoint ligands in PDA. We describe ??T cells as central regulators of effector T cell activation in cancer via novel cross-talk. Twit Text FOAVip T Cells Support Pancreatic Oncogenesis by Restraining T Cell Activation ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27569912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27569912 #FOAvip English Wikipedia <ref>{{Cite pmid|27569912}}</ref> ?? T Cells Support Pancreatic Oncogenesis by Restraining ?? T Cell Activation #MMPMID27569912 Daley D; Zambirinis C; Seifert L; Akkad N; Mohan N; Werba G; Barilla R; Torres-Hernandez A; Hundeyin M; Kumar Mani VR; Avanzi A; Tippens D; Narayanan R; Jang JE; Newman E; Pillarisetty VG; Dustin ML; Bar-Sagi D; Hajdu C; Miller G Cell 2016[Sep]; 166 (6): 1485-1499.e15 PMID27569912show ga Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely-activated ??T cell population which constituted ?40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of ??T cells was contingent on diverse chemokine signals. Deletion, depletion, or blockade of ??T cell recruitment was protective against PDA and resulted in increased infiltration, activation, and Th1-polarization of ??T cells. Whereas ??T cells were dispensable to outcome in PDA, they became indispensable mediators of tumor-protection upon ??T cell ablation. PDA-infiltrating ??T cells expressed high levels of exhaustion ligands and thereby negated adaptive anti-tumor immunity. Blockade of PD-L1 in ??T cells enhanced CD4+ and CD8+ T cell infiltration and immunogenicity and induced tumor-protection suggesting that ??T cells are critical sources of immune-suppressive checkpoint ligands in PDA. We describe ??T cells as central regulators of effector T cell activation in cancer via novel cross-talk. ä?? T Cells Support Pancreatic Oncogenesis by Restraining ?? T Cell Act(epmc).pdf DeepDyve Pubget Overpricing