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10.1016/bs.ctdb.2015.10.002 http://scihub22266oqcxt.onion/10.1016/bs.ctdb.2015.10.002 C5017882!5017882!26970621     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Top+Dev+Biol 2016 ; 116 (ä): 201-29 Nephropedia Template TP {{tp|p=26970621|t=2016. Genome Duplication: The Heartbeat of Developing Organisms |pdf=|usr=}}{{26970621}} gab.com Text Genome Duplication: The Heartbeat of Developing Organisms JO: Curr Top Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26970621 #FOAvip The mechanism that duplicates the nuclear genome during the trillions of cell divisions required to develop from zygote to adult is the same throughout the eukarya, but the mechanisms that determine where, when and how much nuclear genome duplication occur regulate development and differ among the eukarya. They allow organisms to change the rate of cell proliferation during development, to activate zygotic gene expression independently of DNA replication, and to restrict nuclear DNA replication to once per cell division. They allow specialized cells to exit their mitotic cell cycle and differentiate into polyploid cells, and in some cases, to amplify the number of copies of specific genes. It is genome duplication that drives evolution, by virtue of the errors that inevitably occur when the same process is repeated trillions of times. It is, unfortunately, the same errors that produce age-related genetic disorders such as cancer. Twit Text FOAVip Genome Duplication: The Heartbeat of Developing Organisms ????Curr Top Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26970621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26970621 #FOAvip English Wikipedia <ref>{{Cite pmid|26970621}}</ref> Genome Duplication: The Heartbeat of Developing Organisms #MMPMID26970621 DePamphilis ML Curr Top Dev Biol 2016[]; 116 (ä): 201-29 PMID26970621show ga The mechanism that duplicates the nuclear genome during the trillions of cell divisions required to develop from zygote to adult is the same throughout the eukarya, but the mechanisms that determine where, when and how much nuclear genome duplication occur regulate development and differ among the eukarya. They allow organisms to change the rate of cell proliferation during development, to activate zygotic gene expression independently of DNA replication, and to restrict nuclear DNA replication to once per cell division. They allow specialized cells to exit their mitotic cell cycle and differentiate into polyploid cells, and in some cases, to amplify the number of copies of specific genes. It is genome duplication that drives evolution, by virtue of the errors that inevitably occur when the same process is repeated trillions of times. It is, unfortunately, the same errors that produce age-related genetic disorders such as cancer. äGenome Duplication: The Heartbeat of Developing Organisms (epmc).pdf DeepDyve Pubget Overpricing