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2016 ; 57
(5
): 351-6
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Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral
stones: A prospective randomized study
#MMPMID27617317
Kc HB
; Shrestha A
; Acharya GB
; Basnet RB
; Shah AK
; Shrestha PM
Investig Clin Urol
2016[Sep]; 57
(5
): 351-6
PMID27617317
show ga
PURPOSE: This study aimed to compare the safety and efficacy of tamsulosin and
tadalafil as medical expulsive therapy for distal ureteral stones. MATERIALS AND
METHODS: This prospective randomized study was conducted at the Department of
Urology of Bir Hospital over a period of 12 months in patients with distal
ureteral stones sized 5 to 10 mm. Patients were randomly divided into 2 groups:
group A received tamsulosin 0.4 mg and group B received tadalafil 10 mg at
bedtime for 2 weeks. Stone expulsion rate, number of ureteric colic episodes and
pain score, analgesic requirements, and adverse drug effects were noted in both
groups. Statistical analyses were performed by using Student t-test and
chi-square test. RESULTS: Altogether 85 patients, 41 in group A and 44 in group
B, were enrolled in the study. The patients' average age was 31.72±12.63 years,
and the male-to-female ratio was 1.5:1. Demographic profiles, stone size, and
baseline investigations were comparable between the 2 groups. The stone expulsion
rate was significantly higher in the tadalafil group than in the tamsulosin group
(84.1% vs. 61.0%, p=0.017). Although the occurrence of side effects was higher
with tadalafil, this difference was not significant (p=0.099). There were no
serious adverse effects. CONCLUSIONS: Tadalafil has a significantly higher stone
expulsion rate than tamsulosin when used as a medical expulsive therapy for
distal ureteral stones sized 5-10 mm. Both drugs are safe, effective, and well
tolerated with minor side effects.