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10.4111/icu.2016.57.5.351

http://scihub22266oqcxt.onion/10.4111/icu.2016.57.5.351
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suck abstract from ncbi


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pmid27617317
      Investig+Clin+Urol 2016 ; 57 (5 ): 351-6
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  • Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral stones: A prospective randomized study #MMPMID27617317
  • Kc HB ; Shrestha A ; Acharya GB ; Basnet RB ; Shah AK ; Shrestha PM
  • Investig Clin Urol 2016[Sep]; 57 (5 ): 351-6 PMID27617317 show ga
  • PURPOSE: This study aimed to compare the safety and efficacy of tamsulosin and tadalafil as medical expulsive therapy for distal ureteral stones. MATERIALS AND METHODS: This prospective randomized study was conducted at the Department of Urology of Bir Hospital over a period of 12 months in patients with distal ureteral stones sized 5 to 10 mm. Patients were randomly divided into 2 groups: group A received tamsulosin 0.4 mg and group B received tadalafil 10 mg at bedtime for 2 weeks. Stone expulsion rate, number of ureteric colic episodes and pain score, analgesic requirements, and adverse drug effects were noted in both groups. Statistical analyses were performed by using Student t-test and chi-square test. RESULTS: Altogether 85 patients, 41 in group A and 44 in group B, were enrolled in the study. The patients' average age was 31.72±12.63 years, and the male-to-female ratio was 1.5:1. Demographic profiles, stone size, and baseline investigations were comparable between the 2 groups. The stone expulsion rate was significantly higher in the tadalafil group than in the tamsulosin group (84.1% vs. 61.0%, p=0.017). Although the occurrence of side effects was higher with tadalafil, this difference was not significant (p=0.099). There were no serious adverse effects. CONCLUSIONS: Tadalafil has a significantly higher stone expulsion rate than tamsulosin when used as a medical expulsive therapy for distal ureteral stones sized 5-10 mm. Both drugs are safe, effective, and well tolerated with minor side effects.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Analgesics, Non-Narcotic/administration & dosage [MESH]
  • |Diclofenac/administration & dosage/analogs & derivatives [MESH]
  • |Drug Administration Schedule [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pain Measurement/methods [MESH]
  • |Prospective Studies [MESH]
  • |Renal Colic/etiology [MESH]
  • |Sulfonamides/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Tadalafil/administration & dosage/adverse effects/*therapeutic use [MESH]
  • |Tamsulosin [MESH]
  • |Treatment Outcome [MESH]
  • |Ureteral Calculi/complications/*drug therapy/pathology [MESH]
  • |Urological Agents/administration & dosage/adverse effects/*therapeutic use [MESH]


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