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10.1016/j.gde.2016.05.003 http://scihub22266oqcxt.onion/10.1016/j.gde.2016.05.003 C5017534!5017534!27269731     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Genet+Dev 2016 ; 38 (ä): 102-9 Nephropedia Template TP {{tp|p=27269731|t=2016. Mitochondrial Pyruvate Carrier Function and Cancer Metabolism |pdf=|usr=}}{{27269731}} gab.com Text Mitochondrial Pyruvate Carrier Function and Cancer Metabolism JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=27269731 #FOAvip Metabolic reprograming in cancer supports the increased biosynthesis required for unchecked proliferation. Increased glucose utilization is a defining feature of many cancers that is accompanied by altered pyruvate partitioning and mitochondrial metabolism. Cancer cells also require mitochondrial tricarboxylic acid cycle activity and electron transport chain function for biosynthetic competency and proliferation. Recent evidence demonstrates that mitochondrial pyruvate carrier (MPC) function is abnormal in some cancers and that increasing MPC activity may decrease cancer proliferation. Here we examine recent findings on MPC function and cancer metabolism. Special emphasis is placed on the compartmentalization of pyruvate metabolism and the alternative routes of metabolism that maintain the cellular biosynthetic pools required for unrestrained proliferation in cancer. Twit Text FOAVip Mitochondrial Pyruvate Carrier Function and Cancer Metabolism ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=27269731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27269731 #FOAvip English Wikipedia <ref>{{Cite pmid|27269731}}</ref> Mitochondrial Pyruvate Carrier Function and Cancer Metabolism #MMPMID27269731 Rauckhorst AJ; Taylor EB Curr Opin Genet Dev 2016[Jun]; 38 (ä): 102-9 PMID27269731show ga Metabolic reprograming in cancer supports the increased biosynthesis required for unchecked proliferation. Increased glucose utilization is a defining feature of many cancers that is accompanied by altered pyruvate partitioning and mitochondrial metabolism. Cancer cells also require mitochondrial tricarboxylic acid cycle activity and electron transport chain function for biosynthetic competency and proliferation. Recent evidence demonstrates that mitochondrial pyruvate carrier (MPC) function is abnormal in some cancers and that increasing MPC activity may decrease cancer proliferation. Here we examine recent findings on MPC function and cancer metabolism. Special emphasis is placed on the compartmentalization of pyruvate metabolism and the alternative routes of metabolism that maintain the cellular biosynthetic pools required for unrestrained proliferation in cancer. äMitochondrial Pyruvate Carrier Function and Cancer Metabolism (epmc).pdf DeepDyve Pubget Overpricing