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10.1186/s12936-016-1516-y http://scihub22266oqcxt.onion/10.1186/s12936-016-1516-y C5017124!5017124 !27612570     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27612570 &cmd=llinks): Failed to open stream: HTTP request failed! 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Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury |pdf=|usr=}}{{27612570 }} gab.com Text Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury JO: Malar J http://www.kidney.de/pget.php?&tw=1&pmid=27612570 #FOAvip BACKGROUND: Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to explore the predictive performance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for AKI in travellers with imported P. falciparum infection. METHODS: Thirty-nine patients with imported falciparum malaria from the Rotterdam Malaria Cohort with available serum and urine samples at presentation were included. Ten of these patients met the criteria for severe malaria. The predictive performance of NGAL and KIM-1 as markers for AKI was compared with that of serum creatinine. RESULTS: Six of the 39 patients (15 %) developed AKI. Serum and urine NGAL and urine KIM-1 were all found to have large areas under the receiver operating characteristics curves (AUROC) for predicting AKI. Urine NGAL was found to have an excellent performance with positive predictive value (PPV) of 1.00 (95 % CI 0.54-1.00), a negative predictive value (NPV) of 1.00 (95 % CI 0.89-1.00) and an AUROC of 1.00 (95 % CI 1.00-1.00). CONCLUSION: A good diagnostic performance of NGAL and KIM-1 for AKI was found. Particularly, urine NGAL was found to have an excellent predictive performance. Larger studies are needed to demonstrate whether these biomarkers are superior to serum creatinine as predictors for AKI in P. falciparum malaria. Twit Text FOAVip Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury ????Malar J http://www.kidney.de/pget.php?&tw=1&pmid=27612570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27612570 #FOAvip English Wikipedia <ref>{{Cite pmid|27612570 }}</ref> Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury #MMPMID27612570 van Wolfswinkel ME ; Koopmans LC ; Hesselink DA ; Hoorn EJ ; Koelewijn R ; van Hellemond JJ ; van Genderen PJ Malar J 2016[Sep]; 15 (1 ): 464 PMID27612570 show ga BACKGROUND: Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to explore the predictive performance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for AKI in travellers with imported P. falciparum infection. METHODS: Thirty-nine patients with imported falciparum malaria from the Rotterdam Malaria Cohort with available serum and urine samples at presentation were included. Ten of these patients met the criteria for severe malaria. The predictive performance of NGAL and KIM-1 as markers for AKI was compared with that of serum creatinine. RESULTS: Six of the 39 patients (15 %) developed AKI. Serum and urine NGAL and urine KIM-1 were all found to have large areas under the receiver operating characteristics curves (AUROC) for predicting AKI. Urine NGAL was found to have an excellent performance with positive predictive value (PPV) of 1.00 (95 % CI 0.54-1.00), a negative predictive value (NPV) of 1.00 (95 % CI 0.89-1.00) and an AUROC of 1.00 (95 % CI 1.00-1.00). CONCLUSION: A good diagnostic performance of NGAL and KIM-1 for AKI was found. Particularly, urine NGAL was found to have an excellent predictive performance. Larger studies are needed to demonstrate whether these biomarkers are superior to serum creatinine as predictors for AKI in P. falciparum malaria. |Acute Kidney Injury/*diagnosis/*etiology [MESH] |Adult [MESH] |Aged [MESH] |Female [MESH] |Hepatitis A Virus Cellular Receptor 1/*analysis/*blood [MESH] |Humans [MESH] |Lipocalin-2/*blood/*urine [MESH] |Malaria, Falciparum/*complications [MESH] |Male [MESH] |Middle Aged [MESH] |Netherlands [MESH] |Pilot Projects [MESH] |Predictive Value of Tests [MESH] |Prognosis [MESH]Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurre(epmc).pdf DeepDyve Pubget Overpricing