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10.1038/srep33150 http://scihub22266oqcxt.onion/10.1038/srep33150 C5016833!5016833!27608771     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27608771|t=2016. Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry |pdf=|usr=}}{{27608771}} gab.com Text Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27608771 #FOAvip Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children. There is thus an urgent need to find new treatments to control EV71 infection. In this study, we report potent inhibition of EV71 by a polyene antibiotic Amphotericin B. Amphotericin B profoundly diminished the expression of EV71 RNA and viral proteins in the RD cells and the HEK293 cells. As a result, EV71 production was inhibited by Amphotericin B with an EC50 (50% effective concentration) of 1.75??M in RD cells and 0.32??M in 293 cells. In addition to EV71, EV68 was also strongly inhibited by Amphotericin B. Results of mechanistic studies revealed that Amphotericin B targeted the early stage of EV71 infection through impairing the attachment and internalization of EV71 by host cells. As an effective anti-fungi drug, Amphotericin B thus holds the promise of formulating a novel therapeutic to treat EV71 infection. Twit Text FOAVip Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27608771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27608771 #FOAvip English Wikipedia <ref>{{Cite pmid|27608771}}</ref> Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry #MMPMID27608771 Xu F; Zhao X; Hu S; Li J; Yin L; Mei S; Liu T; Wang Y; Ren L; Cen S; Zhao Z; Wang J; Jin Q; Liang C; Ai B; Guo F Sci Rep 2016[]; 6 (ä): ä PMID27608771show ga Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children. There is thus an urgent need to find new treatments to control EV71 infection. In this study, we report potent inhibition of EV71 by a polyene antibiotic Amphotericin B. Amphotericin B profoundly diminished the expression of EV71 RNA and viral proteins in the RD cells and the HEK293 cells. As a result, EV71 production was inhibited by Amphotericin B with an EC50 (50% effective concentration) of 1.75??M in RD cells and 0.32??M in 293 cells. In addition to EV71, EV68 was also strongly inhibited by Amphotericin B. Results of mechanistic studies revealed that Amphotericin B targeted the early stage of EV71 infection through impairing the attachment and internalization of EV71 by host cells. As an effective anti-fungi drug, Amphotericin B thus holds the promise of formulating a novel therapeutic to treat EV71 infection. äAmphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral E(epmc).pdf DeepDyve Pubget Overpricing