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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2016 ; 291 (37): 19235-44 Nephropedia Template TP
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A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis * #MMPMID27474742
Andrew RJ; Kellett KAB; Thinakaran G; Hooper NM
J Biol Chem 2016[Sep]; 291 (37): 19235-44 PMID27474742show ga
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-?. However, recent evidence suggests that the accepted view of APP proteolysis by the canonical ?-, ?-, and ?-secretases is simplistic, with the discovery of a number of novel APP secretases (including ?- and ?-secretases, alternative ?-secretases) and additional metabolites, some of which may also cause synaptic dysfunction. Furthermore, various proteins have been identified that interact with APP and modulate its cleavage by the secretases. Here, we give an overview of the increasingly complex picture of APP proteolysis.