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10.1016/j.celrep.2015.01.025 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.01.025 C5016211!5016211!25683721     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 10 (6): 993-1006 Nephropedia Template TP {{tp|p=25683721|t=2015. Systematic discovery of human gene function and principles of modular organization through phylogenetic profiling |pdf=|usr=}}{{25683721}} gab.com Text Systematic discovery of human gene function and principles of modular organization through phylogenetic profiling JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25683721 #FOAvip Functional links between genes can be predicted using phylogenetic profiling, by correlating the appearance and loss of homologs in subsets of species. However, effective genome-wide phylogenetic profiling has been hindered by the large fraction of human genes related to each other through historical duplication events. Here we overcame this challenge by automatically profiling over 30,000 groups of homologous human genes (orthogroups) representing the entire protein-coding genome across 177 eukaryotic species (hOP-profiles). By generating a full pair-wise orthogroup phylogenetic co-occurrence matrix, we derive unbiased genome-wide predictions of functional modules (hOP-modules). Our approach predicts functions for hundreds of poorly characterized genes. The results suggest evolutionary constraints that lead components of protein complexes and metabolic pathways to co-evolve while genes in signaling and transcriptional networks do not. As a proof of principle, we validated two subsets of candidates experimentally for their predicted link to the actin-nucleating WASH complex and cilia/basal body function. Twit Text FOAVip Systematic discovery of human gene function and principles of modular organization through phylogenetic profiling ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25683721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25683721 #FOAvip English Wikipedia <ref>{{Cite pmid|25683721}}</ref> Systematic discovery of human gene function and principles of modular organization through phylogenetic profiling #MMPMID25683721 Dey G; Jaimovich A; Collins SR; Seki A; Meyer T Cell Rep 2015[Feb]; 10 (6): 993-1006 PMID25683721show ga Functional links between genes can be predicted using phylogenetic profiling, by correlating the appearance and loss of homologs in subsets of species. However, effective genome-wide phylogenetic profiling has been hindered by the large fraction of human genes related to each other through historical duplication events. Here we overcame this challenge by automatically profiling over 30,000 groups of homologous human genes (orthogroups) representing the entire protein-coding genome across 177 eukaryotic species (hOP-profiles). By generating a full pair-wise orthogroup phylogenetic co-occurrence matrix, we derive unbiased genome-wide predictions of functional modules (hOP-modules). Our approach predicts functions for hundreds of poorly characterized genes. The results suggest evolutionary constraints that lead components of protein complexes and metabolic pathways to co-evolve while genes in signaling and transcriptional networks do not. As a proof of principle, we validated two subsets of candidates experimentally for their predicted link to the actin-nucleating WASH complex and cilia/basal body function. äSystematic discovery of human gene function and principles of modular (epmc).pdf DeepDyve Pubget Overpricing