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10.3851/IMP3040

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C5016206!5016206 !26954372
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suck abstract from ncbi


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pmid26954372
      Antivir+Ther 2016 ; 21 (6 ): 553-558
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  • Tenofovir alafenamide as part of a salvage regimen in a patient with multi-drug resistant HIV and tenofovir-DF-associated renal tubulopathy #MMPMID26954372
  • Mikula JM ; Manion MM ; Maldarelli F ; Suarez LM ; Norman-Wheeler JF ; Ober AG ; Dewar RL ; Kopp JB ; Lane HC ; Pau AK
  • Antivir Ther 2016[]; 21 (6 ): 553-558 PMID26954372 show ga
  • We describe a patient with two recent episodes of tenofovir disoproxil fumarate (TDF)-associated acute kidney injury and six-class drug-resistant HIV infection who achieved and maintained viral suppression without worsening kidney function on a regimen including tenofovir alafenamide (TAF) through 48 weeks of therapy. The safety and efficacy of TAF in patients with TDF-associated renal tubulopathy and multiple drug resistant HIV has not yet been described. TAF may represent a useful option to maximally suppress HIV in patients with these complications.
  • |Acute Kidney Injury/*chemically induced/physiopathology [MESH]
  • |Adenine/*analogs & derivatives/therapeutic use [MESH]
  • |Alanine [MESH]
  • |Anti-HIV Agents/*adverse effects/*therapeutic use [MESH]
  • |Drug Resistance, Multiple, Viral/genetics [MESH]
  • |HIV Infections/*drug therapy/virology [MESH]
  • |HIV-1/drug effects/genetics [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Salvage Therapy [MESH]


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