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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Allergy 2016 ; 71 (6): 758-64 Nephropedia Template TP
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TGF-?1-induced transcription factor networks in Langerhans cell development and maintenance #MMPMID26948524
Zhang X; Gu J; Yu FS; Zhou L; Mi QS
Allergy 2016[Jun]; 71 (6): 758-64 PMID26948524show ga
Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-?1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-?1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.