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10.1146/annurev-biochem-060815-014528 http://scihub22266oqcxt.onion/10.1146/annurev-biochem-060815-014528 C5016079!5016079!27145846     free     free     free       Annu+Rev+Biochem 2016 ; 85 (ä): 659-83 Nephropedia Template TP {{tp|p=27145846|t=2016. Mechanisms of Mitotic Spindle Assembly |pdf=|usr=}}{{27145846}} gab.com Text Mechanisms of Mitotic Spindle Assembly JO: Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=27145846 #FOAvip Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ~200 essential MT-associated proteins. Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome segregation is still missing. This is mostly due to the density of MTs in the spindle, which presumably precludes their direct observation. Recent insight has been gained into the molecular building plan of the metaphase spindle using bulk and single-molecule measurements combined with computational modeling. MT nucleation was uncovered as a key principle of spindle assembly, and mechanistic details about MT nucleation pathways and their coordination are starting to be revealed. Lastly, advances in studying spindle assembly can be applied to address the molecular mechanisms of how the spindle segregates chromosomes. Twit Text FOAVip Mechanisms of Mitotic Spindle Assembly ????Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=27145846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27145846 #FOAvip English Wikipedia <ref>{{Cite pmid|27145846}}</ref> Mechanisms of Mitotic Spindle Assembly #MMPMID27145846 Petry S Annu Rev Biochem 2016[Jun]; 85 (ä): 659-83 PMID27145846show ga Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ~200 essential MT-associated proteins. Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome segregation is still missing. This is mostly due to the density of MTs in the spindle, which presumably precludes their direct observation. Recent insight has been gained into the molecular building plan of the metaphase spindle using bulk and single-molecule measurements combined with computational modeling. MT nucleation was uncovered as a key principle of spindle assembly, and mechanistic details about MT nucleation pathways and their coordination are starting to be revealed. Lastly, advances in studying spindle assembly can be applied to address the molecular mechanisms of how the spindle segregates chromosomes. äMechanisms of Mitotic Spindle Assembly (epmc).pdf DeepDyve Pubget Overpricing